INCIDENCE AND COMPARATIVE ANALYSIS OF ADVERSE DRUG REACTIONS IN DOTSAbstract
To assess the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course (DOTS) from previously reported 8 articles from referred sources. Articles related to adverse drug reactions induced by first line anti- tuberculosis drugs in DOTS therapy published during 2002 to 2012 were searched. The incidence rate of each type of ADR from entire ADRs were analyzed and compared. The total 10083 patients from 8 studies were studied, out of those 7473 (74.11%) patients showed at least one type of ADR. The majority cases of ADRs were dermatological reactions occurred in 4389 (43.52%) patients followed by hepatotoxicity in 1634 (16.20%) patients, other reactions related to gastrointestinal (GI) in 1004 (9.95%) patients, central nervous system in 86 (0.85%) patients,peripheral nervous system in 07 (0.069%) patients, psychiatric in 03 (0.029%) patients, musculoskeletal in 166 (1.64%) patients, renal in 07 (0.069%) patients, otological in 09 (0.089%) patients, ocular in 29 (0.28%) patients, fever in 13 (0.12%) patients, breathlessness in 04 (0.039%) patients, headache in 37 (0.36%) patients and miscellaneous ADR in 659 (6.53%) patients. There were many adverse drug reactions observed during study which are needed to be monitored during DOTS therapy for prevention of serious harmful effects like leading to death.
Amitkumar Anandrao Khade* and Vishal Janu Gothal
Government College of Pharmacy, Karad, Maharashtra, India
10 May, 2013
21 June, 2013
27 August, 2013
01 September, 2013