INDIAN NATURAL ZEOLITE CATALYZED SYNTHESIS OF β-AMINOHETERONAPTHOL AND THEIR POTENT ANTIMICROBIAL EFFICACYAbstract
A highly resourceful, elegant, simple and green technique with exceptionally facile reaction conditions of one pot three component reaction was applied to synthesized series of novel mannich base having an array of biologically and pharmaceutically active novel heterocycles. The present protocol offered a valuable alternative to known methods and will find applications in the field of green synthesis and antimicrobial study against pathogenic microbes supports the development of bioinformatical database of novel and abandoned heterocycles. These data indicate their potential to become antimicrobial agents against pathogenic and resistant strains of micro-organisms. The novel products were established by Elemental, IR, mass spectroscopic and 1H, 13C NMR analysis. The environmental advantages of the method include short reaction time, excellent yield, easy work-up, elimination of extraction and chromatographic purification process. The synthesized β-amino-heteronapthols were tested for their antimicrobial efficacy against pathogenic bacteria and fungi by comparing their zone of inhibition with standard antibacterial agents (Gentamicin, Amoxicillin) and antifungal agents (Nistatin, Fluconazole).
Kiran Khandarkar, Manoj Shanti , Mudrika Ahmed , Jyotsna Meshram
Lecturer, G. H. Raisoni Academy of Engineering & Technology, Shraddha Park, Nagpur-440016, Maharashtra, India
06 May, 2013
21 August, 2013
27 September, 2013
01 October, 2013