INFLUENCE OF THE SUPERDISINTEGRANTS IN NIFEDIPINE RELEASE FROM OSMOTIC PUSH-PULL TABLETS
AbstractPush-pull osmotic pumps are controlled drug delivery systems for drugs with a broad range of solubilities; especially drugs that are poorly water-soluble. The aim of the present study was to evaluate the performance of the superdisintegrants (SD), crospovidone (CPVP), croscarmellose sodium (CS), and sodium starch glycolate (SSG), in push-pull tablets containing Nifedipine (NP) as a model drug. We performed an in-vitro dissolution test with phosphate buffer (0.05M) at pH 7.5 for 12 h. The amount of released NP was determined using a UV/Visible spectro-photometric method at a wavelength of 238 nm. At 12 h of release, the profile of CPVP- and CS-containing osmotic tablets was like that of the reference product Adalat OROS®, whereas the SSG-containing tablet showed differences. It is very important mention that in the first 6 h of the assay, all release profiles were different compared to the commercially available reference product. The tablets containing superdisintegrants showed faster drug delivery rates and a reduction in lag time.
Article Information
8
2164-2171
902
1499
English
IJPSR
J. E. Hernández Torres, E. Hernández Baltazar, M. J. B. Bernad and L. M. M. Contreras *
Universidad Autónoma Metropolitana, Unidad Xochimilco, Departamento de Sistemas Biológicos, Calzada del Hueso 1100 Col, Villa Quietud Delegación Coyoacán C.P, México D.F., México.
lmelgoza@correo.xoc.uam.mx
18 August 2018
08 November 2018
17 November 2018
10.13040/IJPSR.0975-8232.10(5).2164-71
01 May 2019
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