INFORMATIVENESS OF EPIGENETIC CHANGES IN THE SIGIRR GENE IN INFANTS WHO DIED FROM NECROTIZING ENTEROCOLITIS
AbstractNecrotizing Enterocolitis (NEC) is a severe gastro-intestinal disease primarily affecting premature infants, especially those born at or before 32 weeks of gestation, and is associated with high morbidity and mortality rates, characterized by intestinal inflammation and necrosis. The purpose of this study was to investigate the role of genetic factors in the development of necrotizing enterocolitis, mortality cases, and potential links between these two conditions. A total of 44 infants were included in this study. Based on survival during the neonatal period, NEC were divided into two subgroups: those who survived (35 infants) and those who died 9 infants). SIGIRR gene methylations were identified through DNA isolation and standard PCR reactions. It was found that changes in the %C33, %C35, %C51 and %C102 gene loci are potential predictive markers for distinguishing infants who died from NEC from those without this pathology Genetic screening could help identify infants at a higher risk of developing NEC, allowing for timely, targeted intervention and personalized care measures.
Article Information
13
2776-2782
585 KB
388
English
IJPSR
A. M. Aliyeva *, A. A. Polukhova, S. R. Nasirova, S. A. Mekhdiyeva and I. A. Gafarov
Department of Newborn Pathologies, Scientific Research İnstitute of Pediatrics Named after K. Y. Farajova, 17 Bagirova str, Baku, Azerbaijan.
dr.aliyeva-a@mail.ru
21 April 2025
14 May 2025
14 June 2025
10.13040/IJPSR.0975-8232.16(10).2776-82
01 October 2025
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