INNOVATIONS IN NASAL FORMULATIONS: ADVANCES IN TREMOR TREATMENT
AbstractTremors are a neurodegenerative disorder (ND) characterized by the involuntary movement of body parts such as the soft palate, hands, jaw, tongue, and head. As of February 2020, the Online Mendelian Inheritance in Man (OMIM) database contained over 594 genetic conditions. Tremors can originate due to improper functioning of certain areas of the brain or due to genetic inheritance and is prominently observed in people above 60 years of age and mostly in males. It is present as symptoms in many neurodegenerative disorders like stroke, Parkinson’s, and multiple sclerosis. Many dosage forms have been developed for the treatment of tremors, which include tablets, transdermal patches, sustained release, injectables, and sublingual. The intranasal route of drug delivery is an emerging type of novel delivery system and can be a useful tool for treatment. By following pathways like the trigeminal and olfactory nerve pathways, prominent drug bioavailability in the brain, rapid absorption of drugs, and reduced side effects are achieved. In this review, we have discussed the classification of tremors, the drugs used by nasal delivery, the barriers in nasal delivery, advanced formulations, and ongoing research in nasal delivery.
Article Information
6
2707-2719
854 KB
128
English
IJPSR
Pokalkar Ushake Monica *, Jawale Priyanka, Vobhilineeni Padmaja and Palavalasa Latish Kumar
Department of Pharmaceutics, G. Pullareddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.
pumonica123@gmail.com
19 March 2025
23 April 2025
26 April 2025
10.13040/IJPSR.0975-8232.16(10).2707-19
01 October 2025
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