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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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LEISHMANICIDAL EFFECTS OF OLEA EUROPAEA LINN. EXTRACT AGAINST PROMASTIGOTE AND AMASTIGOTE FORMS OF SOME LEISHMANIA SPP

Abstract

Here, we evaluated the in vitro antileishmanial activities of Olea europaea linn. leave extract (OLE) on some Leishmania spp. OLE (0–160 ?g/mL) was considered against promastigote and intracellular amastigote forms of L. tropica (MHOM/IR/2002/Mash2) and L. major (MRHO/IR/75/ER) using MTT assay and in a macrophage model, respectively. The obtained findings demonstrated that OLE significantly (?<0.05) inhibited the growth rate of promastigote and amastigotes as a dose and time dependent response. To conclude, the current investigation exhibited effective antileishmanial activity of OLE.

Article Information

46

4869-4874

741

1079

4

English

IJPSR

F. Kheirandish, B. Delfan, S. Fallahi, M. H. Kayedi, M. Rashidipour and S. Jahanbakhsh*

Bam University of Medical Sciences, Bam, Iran.

sarehjahanbakhsh@gmail.com

15 March, 2017

24 May, 2017

17 September, 2017

10.13040/IJPSR.0975-8232.8(11).4869-74

01 November, 2017

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