LOCAL DRUG DELIVERY IN PERIODONTITIS: AN INNOVATIVE TREATMENT MODALITYAbstract
Periodontitis is a destructive inflammatory disease of the periodontium induced by specific microorganisms and requires more specific treatment. The traditional mechanical therapy alone is not sufficient for the treatment of moderate to severe periodontitis because of in accessibility in the deep periodontal pocket and depth of penetration of microorganisms into the periodontal connective tissues. Thus to overcome the limitations of mechanical therapy, local drug delivery into the periodontal pocket is recommended. The local drug delivery of chemotherapeutic agents to the periodontal lesion site has the advantage of loading a higher concentration of drug at the target site minimizing the adverse effect of the drug on the other systems of the body. The local drug delivery system having controlled release should be considered as an adjunctive to mechanical debridement for the treatment of periodontal diseases. This article reviews local drug delivery systems containing antimicrobial agents. Further extensive comparative studies are required to optimize the use of novel drugs in the local drug delivery system to manage periodontal diseases.
Raju Anarthe *, Preeti Kale, Amit Mani and Shriram Kendre
Department of Periodontology, Rural Dental College of Pravara Institute of Medical Sciences- DU Ahmednagar Loni , Maharashtra, India.
14 June 2020
27 January 2021
21 May 2021
01 September 2021