MAGNETIC DRUG DELIVERY IN THERAPEUTICS
AbstractMagnetic modulated drug delivery system addresses the major problem of initial biodistribution of drug carrier. It involves the use of particulate carriers to a localized diseased site. Magnetic microspheres can be used for site-specific drug targeting as in case of tumors, magnetic bioseparation and also can be used for non-targeted drug delivery as in case of contrast agents (MRI) and drug reservoirs that can be activated by a magnet of suitable strength applied outside the body. This delivery system has the distinct advantage of locally congregating high concentrations of the drug at the diseased site thereby minimizing drug requirement and side effects. Though it is expensive and requires high technical approach, it can be adapted to any part of the body. Various magnetic microspheres developed include magnetic nanoparticles, magnetically resealed erythrocytes and magnetic liposomes. Stereotaxis Inc. and FeRx Inc., are major commercial developers of magnetic guidance system for the medical industry
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