MEDICINAL SIGNIFICANCE OF NIGELLA SATIVA AND ITS SEEDS: RECENT UPDATES
HTML Full TextMEDICINAL SIGNIFICANCE OF NIGELLA SATIVA AND ITS SEEDS: RECENT UPDATES
Sharanabasappa B. Patil *, Sreya Bhaduri and Neha Rao
Department of Chemistry, M. S. Ramaiah Institute of Technology, Bangalore, Karnataka, India.
ABSTRACT: N. sativa (black cumin seed) is popularly known for its medicinal significance such as Anticancer, Antioxidant, Anti-microbial, Anti-inflammatory, Anti-ulcer, Anti-parasitic, Anti-histamine, Analgesic, for skin rashes, hair treatment and also used as a flavoring agent. Recent reports reveal that the Nigella sativa seeds exhibit a potent effect on the Covid-19 virus. Further, N. sativa seed can be used to reduce weight as well as increase digestion. In this manuscript, the recent medicinal updates are highlighted. Finally, this review may attract the young researcher to further design and development of the drug.
Keywords: Nigella sativa, Composition and biological activities
INTRODUCTION: The Nigella sativa medicinal plant has various traditional medicinal potential 1 (Ahmad et al. 2013). N. sativa very common spice used in Indian kitchens. N. sativa plant will grow 50 to 60 cm tall with different colour of flowers in different parts of the world 2 (Tembhurne SV et al. 2014). N. sativa popularly known for its medicinal significance such as Anti (cancer, diabetic, bacterial, fungal, viral, inflammatory, oxidative, histaminic, tumor, fibrotic, infertility, convulsant), analgesic, cardiovascular, neuro-protective effect, kidney protection, wound healing, dermatological effects, for skin rashes, for hair treatment and also used as flavoring agent. Recently observed the Nigella sativa seeds showed some potent effect on the Covid-19 virus.
Medicinal Significance of N. sativa:
Anti-cancer Activity: Selma Dagtas et al. 2021 observed that the oral cancer can be treated or managed by consuming whole seed or aqueous seed extract 3. Swamy S. M. et al. 2000 reported the cytotoxicity activity of N. sativa ethyl acetate seed extract against cancer cell lines (P388, Molt4, Wehi 164, HepG2, SW620 and J82). The experimental result reveals that CC-5 showed higher cytotoxic effect 4. Majdalawieh A. F. et al. 2016 reported that the various in-vitro and in-vivo models of N. sativa studied for anti-cancer potential due to its properties of anti-proliferative, pro-apoptotic, anti-oxidant, anti-metastatic.
The results showed the N. sativa with combination with other drug highly effective to protect the growth of the tumour 5. Arshad H. Rahmani et al. 2014 observed the thymoquinone is the major constituent to prevent or treat the cancer. The major constituent of N. sativa has many therapeutic benefits including controlling cancer by suppressing the tumor genes and carcinogens 6.
Anti-diabetic Activity: Kaur G et al. 2018. reported that the combination of Nigella sativa and C. cassia extract mixture were effective for decreasing the blood glucose levels along with the other medication and also reduced lipid profile. Extracts of Nigella sativa has the capacity to regenerate the beta cells of pancreas which induce insulin secretion 7.
Abdelrazek H. M. et al. 2008 reported that the oil of N. sativa showed high potential against various diabetic complications. The experimental study reveals that thymoquinone is the key role for minimizing the diabetic complications 8.
Anti-bacterial Activity: Grzegorz Gawron et al. 2019 observed the antibacterial activity of seed extract of N. sativa showed high potential against all used bacterial strain with a concentration of 4-16 μg/ml 9. Shabina Ishtiaq et al. 2013 reported the the antibacterial activity of various extracts of the N. sativa of different concentration on different strains of bacteria. The most effective extracts were methanolic, ethanolic, chloroform, acetonic and n-hexane. This study shows that most of the bacterial strains common to human diseases can be controlled by using extracts of N. sativa 10.
Mohamed shohayeb et al. 2012 observed the volatile oil and its fractions of Nigella sativa showed potent antibacterial activity against different types of bacteria and fungi. The seed of N. sativa phenol extract effective against Esherichia coli, Bacillus subtilis and Streptococcus faecalis 11.
Mohammad H Islam et al. 2012 reported the distilled methanolic extract was very effective in inhibition of gram positive as well as gram negative bacteria. The extracts of the germination phase had a better inhibitory activity than many other antibiotics due to presence of metabolites in the methanolic extracts 12.
Anti-fungal Activity: The N. sativa medicinal plant showed its potential in many diseases. Shah S B et al. 2018 observed the methanol, ethanol and aqueous extract of N. sativa seed extract effective against all used fungal strains 13. Sheik Noor Mohamed et al. 2015 reported the Nigella sativa seed extract contains more bioactive compounds and all are highly effective against fungal strains 14. Katerina Halamova et al. 2010 observed that dairy industry is affected by the growth of various types of yeast and other fungus. The N. sativa extracts can be used for the inhibition of growth of microorganisms without harming the chemical characteristic of the product 15.
Anti-viral Activity: Badary O. A. et al. 2021 observed the antiviral activity against a SARS CoV-2 and also the molecular docking studies results showed that the important constituent of N. sativa, thymoquinone can inhibit the COVID-19. The whole world is fighting against the covid-19 virus and there is no treatment found for it. The researchers and scientist are trying out different combination of various anti-viral and antibiotics. The N. sativa plant constituent can be (Thymoquinone) used in the past to treat avian influenza virus 16. Ajaz Ahmad et al. 2020. reported that for corona virus infection if the cells are treated with black seed extracts the replication and virus load decreases 17.
Alam Kulyar M et al. 2020 observed the important composition of N. sativa are the evidence for its medicinal significance and docking study results reveal that N. sativa givemore or similar effect against COVID-19 virus 18.
Umar et al. 2015 conducted experiment on turkey’s infected by H9N2 avian influenza virus. The birds treated with extracts of N. sativa had higher anti-body and immunomodulatory nature. Suppose it is used with 3% amount with dietary supplements enhances immunity and suppress pathogenicity of the influenza virus 19. A. A. Onifade et al. 2015 reported the black cumin and honey mixture highly effective against HIV infection if it is used for a year 20.
Anti-inflammatory and Analgesic Activity: Harshal N Pise et al. 2017 conducted a test for comparing the effect of N. saliva along with other drugs. The steroidal anti-inflammatory can be used for long term as it has toxins and other side effects. The experimental observations of N. sativa oil showed potent anti-inflammatory properties 21.
Alireza Ghannadi et al. 2005. reported the N. sativa seed exhibited potent anti-inflammatory and analgesic effects studied in mice and rats by using tail flick and carrageenan induced paw edema method 22.
Antioxidative and Anti-histaminic Activity: Kanter Metal et al. 2006. Observed the thymoquinone is the important constituent of N. sativa has more medicinal significance such as antioxidant and antihistaminic properties 23. M. H. Boskabady et al. 2002 reported the N. sativa extract highly effective to prevent the lung inflammation in guinea pigs 24.
Cardiovascular Effects: Cardiovascular diseases are a class of heart problems (diseased vessels, structural problems and blood clots). Hypertension is a major cause of cardiovascular disease in the world. Enayatfard L et al 2019. found that a hydroalcoholic extract of N. sativa and TQ considerably reduced the cardiovascular responses. The Wistar rats were separated into groups and pre-treated with three doses of N. sativa (200, 400, and 600 mg/kg) administered intraperitoneally. After which the angiotensin II was injected. The experimental results reveal that N. sativa exhibits well anti cardiovascular effects 25.
Ahmed M et al. 2013. carried out a study to evaluate the cardio-protective effect of Nigella sativa oil. Nigella sativa oil administration resulted in considerable stabilization of physiological parameters, regeneration of histological structure, and suppression of cyclooxyenase-2 expression in the heart when compared to the Pb group. In lead-induced cardio toxicity 26.
Anti-tumor Effect: The present evidence strongly suggests that N. sativa could be used alone or with the combination to suppress tumor genesis, growth, and metastasis. The main constituent of N. sativa is Thymoquinone (TQ) which has a major action in anti-tumour effect 27. Tabasi N et al. 2014 observed that the TQ oral administration resulted in suppression of stomach tumor in mice 28.
Linjawi and his co-workers reported the effects of Thymoquinone (TQ) and black cumin seed oil on tumor markers. Parenteral TQ (1–10 mg/kg) or N. sativa oil (three times a week for four months) protected female rats from developing breast cancer 29. Black cumin seed has also been shown to protect and limit the growth and spread of cancer-causing neoplastic cells.
Anti-fibrotic Effect: Al-Gayyar et al. 2016 reported the effects of oral sodium nitrite on kidney function in rats as well as the possible protective benefits of NSO. Based on their findings, NSO when injected in sodium nitrite treated rats in a dose-dependent manner of 2.5, 5 and 10 ml/kg for 12 weeks, showed progressive development of tubulointerstitial fibrosis 30.
Elmowafy M et al. 2016 reported the TQ's antifibrotic properties are mainly due to its anti-oxidant action, which results in less hepatocyte damage and hence less hepatic stellate cell transactivation (HSCs). TQ's role in directly suppressing the fibro genic activity of HSCs, in particular, has not been investigated yet 31.
Neuro-protective Effect: TQ has a good safety profile and is well tolerated for the treatment of neurological illnesses. TQ's neuroprotective impact was tested in a temporal lobe epileptic diseased brain model. Landucci E et al. 2021 observed in his experiment conducted that TQ increases the PSD95 levels in basal conditions. Its neuroprotective effects may be mediated by antioxidant, free radical quenching, and anti-inflammatory activities 32.
Tabeshpour et al. 2019. treated rats with ACR for 11 consecutive days which showed limb amputation. TQ was dissolved in 0.9% NaCl solution in the experiment. Wistar rats exposed to ACR (50 mg/kg, intraperitoneal, for 11 days) showed behavioral changes and weight loss.
Whereas rats that were administered with TQ (5 and 10 mg/kg, i.p., for 11 days) along with ACR, showed reduced or no evidence of paralysis in their limbs 33. Asiaei F et al. 2017. observed the effect of Nigella sativa alcoholic extract on hippocampal volume, number of dark neurons, and apoptotic cells in hypothyroidism rats' hippocampus during the neonatal and juvenile period. The rats of experimental groups that included propylthiouracil (PTU) + N. sativa extract. Different doses of N. sativa hydro alcoholic extract reduced hypothyroidism-induced hippocampus neuronal damage 34.
Kidney Protection: Kidney protection includes acute renal failure, acute kidney injury, kidney stones, and kidney damage due to effect of drugs. Kidney toxicity is caused by increased free radical production, suppression of antioxidant defense mechanisms and acute renal tubular cell necrosis, which leads to kidney failure and a reduced glomerular filtration rate 35. Hannan et al. 2021. reviewed that Thymoquinone, a bioactive component of Black Cumin (Nigella sativa), protects against Kidney Injury by harmful pesticides, heavy metals and some drugs. Black cumin seed oil is use to normalize the blood and urine parameters 36.
Benhelima A et al. 2016. studied the outcome of treating lithiasic Wistar rats with N. sativa extract for nephroprotective and diuretic effect. The study mainly focused on calcium oxalate urolithiasis. The study found that giving 5 ml/kg body weight/dose/day for 28 days has a protective impact by lowering urine and serum calcium, phosphate, and oxalate levels considerably. This preventive diet was also observed to increase the amount of urine output 37.
Jaswal A et al. 2022. investigated defensive role of N. sativa against antituberculosis drugs induced renal toxicity. It was found that kidney can be protected from drug induced renal disorder or nephrotoxicity by using ethanolic extract of N. sativa. It indicates a reduction in serum urea, creatinine, uric acid, urea nitrogen levels, whereas improvement in histological tubular and glomerular damage. This is found to be very useful during anti TB treatment 38.
The effectiveness of black seed in the treatment of kidney stones was investigated by Ardakani Movaghati et al 2019. Based on the results of preclinical studies it reveals that consuming N. sativa seeds prevents formation of renal stones and eliminate early-stage stones. Based on experimental observations N. sativa powder capsules 500 mg made & given to the patients twice a day for 10 weeks and the results showed 44.4% patient excreted the stone and 51.8% the size of the stone decreased meanwhile 3.1% the stone remained unchanged and also they reported for treating larger stones concentrated solution of the seed extract can be used an Alcoholic extract of N. sativa reduces calcium oxalate deposition in kidney as well as in the urine 39.
Wound Healing: Healing of wound refers to a series of events that result in the replacement of missing tissue to the greatest extent possible 40.
In diabetic male rats, the effect of hydroethanolic Nigella sativa L. extract on skin wound healing was investigated by Nourbar E et al. 2016.
The experimental study involved diabetic and non-diabetic rats treated with phenytoin and hydroethanolic extract of N. sativa 20% and 40%. According to the observations diabetic untreated group cured in 27 days, diabetic phenytoin treated group cured in 24 days 41.
Sarkhail P et al. 2011. studied burn healing potential of N. seed oil in rats. The experimental study reveals that n-hexane extract of N. sativa seeds external application on burn wound increases the healing rate as compared with control group. After 16 days of application of the extract 96% of wound was cured. It was also reported that Silver sulfadiazine shows better wound contraction (97% after 16 days) but excessive use can lead to toxicity 42.
Anti-Infertility: Infertility, which leads to unintentional childlessness, is a social and clinical issue that affects couples all over the world. Male factors make up more than half of over all cases of infertility in infertile couples. M. Kolahdooz et al 2014 studied the effects of Nigella sativa L. seed oil on infertile men's aberrant semen quality were investigated.
Fatty acid content and chemical composition of N. sativa oil was examined. In the study the infertile men were given 2.5ml of N. sativa oil twice a day and it was observed that the sperm count increased from 43.53 ± 4.94 to 60.18 ± 5.16. Also, the other semen parameters were improved as compared to placebo effect (treated with 5ml mineral oil) 43.
Anti-convulsant: Chemically induced seizures in albino rats were used to test the anticonvulsant efficacy of a volatile oil extract of Nigella sativa seeds by Bepari A et al. 2016.
Different dosage of N. sativa oil was studied and compared with conventional treatment using sodium valproate. The experimental study concluded that the use of sodium valproate in epilepsy treatment can be reduced by combining it with N. sativa oil and thus can reduce the adverse effect of Sodium Valproate 44.
Dermatological Effects:
Sun Protection: Shantanu et al 2010. studied the sun protection effect of N. sativa oil. In the experimental study N. sativa oil was extracted by petroleum ether in 40-60°C and sunscreen was formulated using this oil. Sunscreen with an SPF of more than 2 is considered to have good sunscreen action. In this investigation, designed sunscreen cream was determined to be in the middle of the range. As a result, Nigella sativa has a high level of sunscreen action. Seed oil has the potential to be a viable option for use as a sunscreen or cosmeceutical 45.
Acne Treatment: One of the most prominent skin problems is acne vulgaris, which is a chronic inflammatory multifactorial condition of the pilosebaceous follicles. It is most usually linked with adolescence, when androgen production is at its highest, but it can affect individuals of any age or ethnicity 46. Soleymani S et al. 2020. performed a preclinical trial on the effect of a hydrogel. According to preclinical studies the hydroethanolic extract of N. sativa was used to prepare the hydrogel. Based on the results of the preclinical studies the treatment essentially decreased the check of skin break out injuries counting comedowns, papules and pustules. Also, this formulation is well suited in most of the patient and can be considered as a natural remedy 47.
Vitiligo: In vitiligo, the skin's melanocytes (pigment-producing cells), mucous membrane and retina are damaged, resulting in white spots in various places of the skin 48. Ghorbanibirgani A et al. 2014. studied comparison between N. sativa and fish oil in treating vitiligo. Based on the clinical trial 96% ethanol was used to extract N. sativa oil and it was made alcohol free by evaporation. The recovery of skin lesions was found to be more significant as compared to fish oil.
Patients who used topical Nigella sativa saw a decrease in their VASI score from 4.98 to 3.75 after six months, while those who used topical fish oil saw a decrease from 4.98 to 4.62. N. sativa can also distribute melanin pigment across the skin by enhancing the sensitivity of cholinergic receptors in the melanopsin, that is also found on the lizard's skin. So, it can be used as a treatment for skin pigmentation 49.
Anti Hair-fall: Mahmoudvand H. et al. 2014. studied the effect of various N. sativa seeds extracts on dermatitis. One of the main reasons from hair-fall is dermatitis. Dermatophytes are one of the most important genera of fungi that cause illnesses in humans and animals all over the world. They have the potential to infect keratinized tissues like hair, skin and nails, causing an ailment known as ringworm. According to the study essential oil, methanolic extract, aqueous extract of Thymoquinone Fluconazole and Ketoconazole were used against pathogenic dermatophyte strains T. mentagrophytes, M. canis and M. gypseum. Based on the results thymoquinone had the lowest MIC and shows more significant results as compared to control group 50.
Other Effect of N. sativa Seed: The seeds of N. sativa if taken in small quantities as flavoring agent in food or as medicine it generally does not have any side effects for most of the humans. But people who consume other medicines might see some side effects due to reactions with some chemical compound.
Some of the rare side effects of N. sativa:
- Allergic rashes when the black seed oil is applied on the skin.
- Stops uterus from contracting if taken in large amount so should be avoided during pregnancy.
- Lower blood sugar and blood pressure, hence the consumption should be monitored.
These side effects occur when the consumption is more than dietary level and when the person in under other medications. The biological potential of other versatile molecules like Coumarin & Pyrimidine acting as CNS depressants, antimicrobial agents, natural product extraction and its biological potential & also our previous group contribution 51-61.
CONCLUSION: The N. sativa has much therapeutic potential with no or least side effects. Many studies have shown positive results of treating many diseases using these seed as well as the oil (Anticancer, Antioxidant, Antimicrobial, Anti-inflammatory, Antiulcer, Antiparasitic, Antihistamine, Analgesic, for skin rashes, for hair treatment and also used as Flavoring agent). Further, the extracts of seed also used in the food preservative industries. Especially in the case of the diseases like cancer and diabetes which has treatments with a lot of side effects. Finally, a lot of study is being done to synthesize these compounds with better improvements to enhance the medicinal uses as natural remedies.
Funding Support: This review article is not supported by any funding.
ACKNOWLEDGMENTS: Authors are thankful to HOD Chemistry, MSRIT for his constant support and Management of the college for providing necessary facility for writing this review article.
CONFLICTS OF INTEREST: None.
REFERENCES:
- Ahmad: A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed 2013; 3, 337–352. doi:10.1016/S2221-1691(13)60075-1.
- Tembhurne SV: A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res 2014; 8:166–167.doi.org/10.5897/JMPR10.737.
- Selma Dagtas: Nigella sativa extract kills premalignant and malignant oral mouscellcarcinomacells, J Herb Med 2021; 29: 100473. doi:10.1016/j.hermed.2021.100473.
- Swamy SM: Cytotoxic andimmune potentiating effects of ethanolic extract of Nigella sativa seeds. Journal of Ethnopharmacology 2000; 70(1): 1–7. doi:10.1016/s0378-8741(98)00241-4.
- Majdalawieh AF: Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. Journal of Ayurveda and Integrative Medicine 2016; 7(3):173–180.doi:10.1016/j.jaim.2016.07.004.
- Arshad H Rahmani: Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways. Evidence-Based Complementary and Alternative Medicine 2014; 1–13. doi:10.1155/2014/724658.
- Kaur G: A nutraceutical combination of Cinnamomum cassia & Nigella sativa for Type 1 diabetes mellitus. Journal of Ayurveda and Integrative Medicine 2018; 9(1): 27–37. doi:10.1016/j.jaim.2017.02.005.
- Abdelrazek HM: Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats .Oxidative Medicine and Cellular Longevity. 2018; 1-10.doi:10.1155/2018/8104165.
- Grzegorz Gawron: Nigella sativa seed extract applicability in preparationsagainstmethicillin-resistant Staphylococcus aureus and effects on human dermal fibro blasts viability. J Ethno Pharmacol 2019; 15(244): 112135. doi:10.1016/j.jep.2019.112135.
- Shabina Ishtiaq: Phytochemical Analysis of Nigella sativa and its Antibacterial Activity against Clinical Isolates Identified by Ribo typing. International Journal of Agriculture & Biology 2013; 12(797):1151–1156.
- Mohamed Shohayeb: Comparative antimicrobial activity of some active constituents of N. sativa. World Applied Sciences Journal 2012; 20(2): 182-189. doi:10.5829/idosi.wasj.2012.20.02.7156.
- Mohammad Hayatul Islam: Antibacterial activity of Nigella sativa seed invarious germination phases on clinical bacterial strains isolated from human patients. E3 Journal of Biotechnologyand Pharmaceutical Research 2012; 4(1): 8-13.
- Shah SB: Effect of Nigella sativa seeds extracts on clinically important bacterial and fungal species. MOJ BioequivAvailab 2018; 5(4): 218-221. doi:10.15406/mojbb.2018.05.00105.
- Sheik Noor Mohamed: A study on the in vitro Antifungal Activity of Nigella sativa (Linn.) Seed extract and its Phytochemical Screening using GC-MS analysis. World Journal of Pharmacy and Pharmaceutical Sciences 2015; 4(08): 1003-1011.
- Katerina Halamova: In-vitro Antifungal Effect of Black Cumin Seed Quinones against Dairy Spoilage Yeasts at Different Acidity Levels. Journal of Food Protection. 2010; 73(12): 2291–229. doi.org/10.4315/0362-028X-73.12.2291.
- Badary OA: Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure. Drug Des Devel Ther 2021; 15: 1819-1833. doi.org/10.2147/DDDT.S308863.
- Ajaz Ahmad: Covid-19 and Thymoquinone: Connecting the Dots. Phyto therapy Research 2020.doi:10.1002/ptr.6793.
- Alam Kulyar: Potential influence of Nagella sativa (BlackCumin) in reinforcing immunesystem: COVID-19 pandemic. Phytomedicine 2020; 153277. doi:10.1016/j.phymed.2020.153277.
- Umar S: Effects of Nigella sativa on immune responses and pathogenesis of avianinfluenza (H9N2) virusin turkeys. The Journal of Applied Poultry Research 2015; 25(1): 95–103. doi:10.3382/japr/pfv070.
- Onifade AA: “Sero negative conversion of an HIV positive subject treated with Nigella sativa and honey”. African Journal of Infectious Diseases 2015; 9( 2): 47–50.
- Harshal N Pise: Evaluation of anti-inflammatory activity of Nigella sativa: An experimental study. National Journal of Physiology, Pharmacy and Pharmacology 2017; 7(7); 707-771.
- Alireza Ghannadi: An investigation of the analgesic and anti-inflammatory effectsof Nigella sativa seed polyphenols, Journal of Medicinal Food 2005; 29. doi:10.1089/jmf.2005.8.488.
- Kanter M: The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. ArchToxico 2006; l80: 217–224.doi.org/10.1007/s00204-005-0037-1.
- Boskabady MH: Inhibitory Effect of Nigella sativa on Histamine (H1) Receptors of Isolated Guinea Pig Tracheal Chains, Pharmaceutical Biology. 2002; 40: 8, 596-602. doi:10.1076/phbi.40.8.596.14653.
- Enayatfard L: The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats. Journal of basic and clinical physiology and pharmacology 2019; 30(1), 51-58. doi: 10.1515/jbcpp-2018-0074.
- Ahmed M: Cardio protective effects of Nigella sativa oil on lead induced cardio toxicity: Anti inflammatory and antioxidant mechanism. Journal of Physiology and Pathophysiology. 2013; 4(5): 72-80. doi: 0.5897/JPAP2013.0083.
- Badary O: Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer detection and prevention. 2001; 25(4): 362-368.
- Tabasi N: Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin. Food and Agricultural Immunology 2015; 26(1): 138-156. doi: 10.1080/09540105.2013.878899.
- Linjawi SA: Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats. Archives of medical science: AMS 2015; 11(1): 220. doi: 10.5114/aoms.2013.33329.
- Al-Gayyar M: Nigella sativa oil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis. Redox Report 2016; 21(2): 50-60. doi: 10.1179/1351000215Y.0000000035.
- Elmowafy M: Enhancement of bioavailability and pharmacodynamic effects of thymoquinone via nanostructured lipid carrier (NLC) formulation. Aaps Pharmscitech 2016; 17(3): 663-672. doi: 10.1208/s12249-015-0391-0.
- Landucci E: Neuro protective effects of thymoquinone by the modulation of ER Stress and apoptotic pathway in-vitro model of excitotoxicity. Molecules 2021; 26 (6), 1592. doi:10.3390/molecules26061592.
- Tabeshpour J: Neuroprotective effects of thymoquinone in acrylamide-induced peripheral nervous system toxicity through MAPKinase and apoptosis pathways in rat. Neurochemical Research 2019; 44(5): 1101-1112. doi: 10.1007/s11064-019-02741-4.
- Asiaei F: Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study. Metabolic brain disease. 2017; 32(5): 1755-1765. doi: 10.1007/s11011-017-0025-1
- Nasri: Tubular kidney protection by antioxidants. Iranian journal of public health 2013; 42(10), 1194.
- Hannan: Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights. International Journal of Molecular Sciences. 2021; 22(16), 9078. doi.org/10.3390/ijms22169078.
- Benhelima A: Nephroprotective and diuretic effect of Nigella sativa L seeds oil on lithiasicwistar rats. African Journal of Traditional, Complementary and Alternative Medicines 2016; 13(6), 204-214.
- Jaswal A: Defensive role of Nigella sativa against antituberculosis drugs induced renal toxicity. Toxicology Research 2022; doi.org/10.1093/toxres/tfac014.
- Ardakani Movaghati: Efficacy of black seed (Nigella sativa) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial. Phytotherapy Research 2019; 33(5): 1404-1412. doi.org/10.1002/ptr.6331.
- Demidova-Rice: Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 1: normal and chronic wounds: biology, causes, and approaches to care. Advances in skin & wound care 2012; 25(7), 304. doi.org/10.1097%2F01.ASW.0000416006.55218.d.
- Nourbar E: Effect of hydroethanolic extract of Nigella sativa on skin wound healing process in diabetic male rats. International Journal of Preventive Medicine 2019; 10. doi.org/10.4103%2Fijpvm.IJPVM_276_18.
- Sarkhail P: Burn healing potential of Nigella sativa seed oil in rats. International Journal of Pharmaceutical Sciences and Research 2011; 2(1): 34.
- Kolahdooz M: Effects of Nigella sativa seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 2014; 21(6): 901-905. doi.org/10.1016/j.phymed.2014.02.006.
- Bepari A: Evaluation of anticonvulsant activity of volatile oil extract of Nigella sativa seeds by chemically induced seizure model in albino rats. Int J Basic Clin Pharmacol 2016; 5, 1300-1307.
- Shantanu K: Formulation and in-vitro determination of sun protection factor of Nigella sativa seed oil sunscreen cream. International Journal of PharmTech Research. 2010; 2(4): 2194-2197.
- Zouboulis C: What is the pathogenesis of acne? Experimental Dermatology 2005; 14(2), 143–143, 152.
- Soleymani S: The effect of a hydrogel made by Nigella sativa on acne vulgaris: A randomized double‐blind clinical trial. Phytotherapy Research 2020; 34(11): 3052-3062.doi.org/10.1002/ptr.6739.
- Burns T: Griffiths C. Rook's Textbook of Dermatology. Oxford. Blackwell Science 2010; 164(6).
- Ghorbanibirgani A: Comparing Nigella sativa oil and fish oil in treatment of vitiligo. Iranian Red Crescent Medical Journal 2014; 16(6). doi.org/10.5812%2Fircmj.4515.
- Mahmoudvand H: Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains. Journal de mycologiemedicale. 2014; 24(4), e155-e161. doi.org/10.1016/j.mycmed.2014.06.048.
- Goudgaon NM: CNS depressant activity of some novel 5-substituted pyrimidin-2,4,6-Triones. Journal of Pharmacy Research 2011; 4(7): 2195-2196.
- Goudgaon NM: Synthesis and Antimicrobial evaluation of 5- iodopyrimidine analogs Indian J Pharm Sci 2009; 71 2009 672 10.4103/ 0250-474X.59551.
- Goudgaon NM: Synthesis of 2-benzylthiopyrimidinyl Pyrazole analogs and their antimicrobial activities, Indian, J Heterocycl Chem 2009; 18: 349–352.
- Goudgaon NM: Synthesis and antimicrobial activity of novel coumarone analogues. Int J Pharm Sci Res IJPSR 2019; 10(2): 960–965.
- Goudgaon NM: Synthesis and antimicrobial activities of novel 5-substituted pyrimidin-2,4,6-triones. J Indian Chem Soc 2010; 87: 743–748.
- Goudgaon NM: A facile route for the synthesis of novel 2-benzylthio-4,6- disubstituted pyrimidine analogues. Ind J Heterocycl Chem 2012; 21: 221–224. doi.org/ 10.13040/IJPSR.0975-8232. 10(2).960-65.
- Patil SB: Medicinal Significance of Benzimidazole Analogues: A Review.IJPSR. 2020; 11(6).2649-54. doi: 10.13040/IJPSR.0975-8232.
- Sharanabasappa B. Patil: Synthesis of 3-(Benzo(D)imidazol-2-yl Amino)-2-(3-Aryl-1Phenyl-1h-Pyrazol-4-yl) Thiazolidin-4-ones. Indian Journal of Heterocyclic Chemistry 2010; 19: 307-308.
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- Sreeja V: Study of Mechanical Properties of Steel Quenched in a Blend of Biodegradable Oils with Quench Accelerators. International Journal of Latest Technology in Engineering, Management & Applied Science (ISSN: 2278-2540) 2016; V (V), 20-24.
- Shivraja: A combined spectroscopic and TDDFT investigation of the solute-solvent interactions of two coumarin derivatives. Luminescence 2017; 1-11. doi: 10.1002/bio.3329.
- Goudgaon NM: Synthesis and Anti-microbial activity of Thiazole substituted Coumarins, Heterocyclic Commu 2009; 15 (5):343–348. doi. org/10.1515/HC.2009.15.5.343.
How to cite this article:
Patil SB, Bhaduri S and Rao N: Medicinal significance of Nigella sativa and its seeds: recent updates. Int J Pharm Sci & Res 2023; 14(9): 4277-84. doi: 10.13040/IJPSR.0975-8232.14(9).4277-84.
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Article Information
6
4277-4284
498 KB
447
English
IJPSR
Sharanabasappa B. Patil *, Sreya Bhaduri and Neha Rao
Department of Chemistry, M. S. Ramaiah Institute of Technology, Bangalore, Karnataka, India.
sbp7910@gmail.com
10 December 2022
12 March 2023
28 April 2023
10.13040/IJPSR.0975-8232.14(9).4277-84
01 September 2023