MICROBIAL L-ASPARAGINASE: A REVIEW ON CURRENT SCENARIO AND FUTURE PROSPECTS
AbstractL-Asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. This article has briefly touched nearly all the industrial and clinical aspects of L-Asparaginase and provides the recent update of the topic. The article includes a brief introduction to the topics, mechanism of action, a little information about the structure, sources of enzyme, purification, optimum conditions for the enzyme production, recombinant strains for higher productivity and formulation of the enzyme.
Article Information
20
3076-3090
762KB
2280
English
IJPSR
S. Kumar Jha*, Divya Pasrija, Rati Kumari Sinha, Hare Ram Singh, Vinod Kumar Nigam and Ambrish Sharan Vidyarthi
Department of Biotechnology, BIT Mesra, Ranchi, Jharkhand, India
skjha@bitmesra.ac.in
05 May, 2012
12 July, 2012
16 August, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3076-90
01 September, 2012
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