MOLECULAR DOCKING STUDIES OF ORGANOSULFUR COMPOUNDS AND FLAVONOIDS OF ALLIUM SATIVUM AGAINST EGFR TO TREAT NON-SMALL CELL LUNG CANCER
AbstractLung cancer is one of predominant cancer which leads to death in the developed and developing countries. 80% of lung cancer cases in India are reported as Non-Small Cell Lung Cancer (NSCLC). EGFR (Epidermal growth factor receptor) that belongs to the tyrosine kinase family (RTKs) is the key paradigm of molecular targeted therapy of lung cancer. Garlic (Allium sativum) is a common Indian spice that belongs to the Allium family, is capable of allowing cancer cell death normally, the process called apoptosis. The therapeutic effect of garlic is due to the presence of its bioactive constituents, including the organosulfur compounds and flavonoids. Molecular docking studies using AutoDock provide the comprehensive binding of bioactive compounds of garlic with EGFR that may lead to its effective inhibition. The current study paves the way for understanding the binding of garlic’s bioactive compounds against EGFR, and it can act as a potential lead molecule for the development of anti-cancer agents.
Article Information
18
4186-4193
939
1300
English
IJPSR
R. Padmini and M. Razia *
Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal, Tamil Nadu, India.
razia581@gmail.com
13 December 2018
17 March 2019
28 March 2019
10.13040/IJPSR.0975-8232.10(9).4186-93
01 September 2019
Download