MOLECULAR MAVERICKS: EXPLORING CARBAMATE-HETEROCYCLE CONJUGATES IN THE QUEST FOR EFFECTIVE ALZHEIMER’S THERAPY
AbstractAlzheimer’s Disease is considered as the most common form of dementia, contributing to about 70% of the cases. The FDA approved Acetyl cholinesterase inhibitors and NMDA receptor antagonists only produce a symptomatic relief and raises the need for novel potential drug candidates for AD management. The various hypotheses on Alzheimer’s Disease reveal its multifactorial nature and thus these multiple targets can be considered for the development of new drug molecules. In this study we focus on designing new carbamate- heterocycle molecules with different heterocycles indole, isoquinoline, thiazole, oxazole and 1,2,4- triazines and identifying their multitarget potential through computer aided drug design. The proposed conjugates were docked with the targets Acetyl cholinesterase (AChE), N-methyl- D- Aspartate Receptor (NMDA), and Tyrosinase enzyme. The results indicated that the compound ISO-10 exhibits a high binding affinity for three targets. The target 1FSS demonstrated the highest binding affinity of the three and is suitable for molecular simulation.
Article Information
16
2275-2293
2432 KB
30
English
IJPSR
Sherin A. Hameed *, N. Fathima, S. Gadha, M. S. Gopika, R. V. Namitha and Sahadiya
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala, India.
sherinirshad@gmail.com
14 March 2025
30 March 2025
15 April 2025
10.13040/IJPSR.0975-8232.16(8).2275-93
01 August 2025
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