MORPHOLOGICAL STUDY OF MIDDLE CRANIAL FOSSA AND ITS VARIATIONS
HTML Full TextMORPHOLOGICAL STUDY OF MIDDLE CRANIAL FOSSA AND ITS VARIATIONS
P. K. Sankaran*, Gunapriya Raghunath, Rohini Arathala, Karthikeyan, Menaka, Madhumitha, M. Yuvaraj and M. Kumaresan
Department of Anatomy, Saveetha Medical College, Thandalam, Chennai - 602105, Tamil Nadu, India.
ABSTRACT: Purpose: To study the morphological details and analyse the morphometry of the various foramens in the dry human skulls of mainly Indian population. Materials and Methods: 64 dry skulls of unknown sex and of Indian origin were used in this study which was carried out at the Department of Anatomy and forensic department of Saveetha Medical College and Hospital in the year 2016. The parameters used were incidence, longitudinal diameter, transverse diameter, distance from midline, distance from petrous apex, and distance between right and left foramen. Result: The mean sizes of the foramen ovale on the right and left sides were 7.45 x 1.1 mm and 7.61 x 1.15 mm. We found that completely ossified pterygospinous ligament passed immediately inferior to the foramen ovale and also presence of bony septa within the foramen. The foramen spinosum was present bilaterally in 90% of the skulls. The mean sizes on the right and left sides were 2.54 x 0.8 mm and 1.97 x 0.7 mm. Foramen Vesalius is one of the most inconsistent foramen of the skull. In this present study this foramen was present in only 25% of the studied skulls. The measured mean longituidinal and transverse diameters optic canal were 5.21, 4.64(mm). Conclusion: Results shows comparison of mean and standard deviation of maximum dimensions of the right and left sided foramens of the middle cranial fossa. No statistically significant differences between both sides were observed except the carotid canal. The results of this study can be helpful for anatomists and surgeons who approach the middle cranial fossa for various procedures.
Keywords: |
Foramina-Middle cranial fossa, Foramen rotundum, Foramen lacerum, Foramen ovale, Foramen spinosum, Carotid canal, Foramen of vesalius
INTRODUCTION: Middle cranial fossa is the center most of the three fossae in the base of skull. It lodges the temporal lobes of the cerebral hemispheres and pituitary gland. It is formed by the body and greater wing of sphenoid bone, part of temporal bone, parts of the parietal bone. Though this fossa is structurally very complicated it is interesting to explore it.
The base of the skull has many foramina which provide communication between extra-cranial and intracranial structures through the blood vessels and nerves passing through it. The greater wing of the sphenoid has three consistent foramina. These are foramen ovale, foramen spinosum, foramen rotundum. The foramen rotundum (FR) is situated just below and behind the medial end of the superior orbital fissure and leads forwards into the pterygopalatine fossa, to which it transmits the maxillary nerve. Posterolateral to the foramen rotundum (FR) is the foramen ovale (FO) which transmits the mandibular nerve. Behind the FO is the foramen spinosum (FS), which transmits the middle meningeal artery 1.
Apart from these foramina the base of the skull has various foramens like Foramen of Vesalius, Canaliculus innominatus, foramen lacerum, carotid canal, optic canal and two small canaliculi named as mastoid and tympanic canaliculi. The dimensions of the foramina and variations in the same are clinically significant in view of the delicate neurovascular structures that traverse them2.
The present study focused on various foramens of the base of the skull with its dimensions and their distances from the median plane and petrous apex, and also occurrence of accessory foramina. Since these foramens act as a gateway for certain neurovascular structures study of base of the skull has an important role in view of its clinical significance. Any trauma or space-occupying lesion in this area would result in compressive forces, with the resulting clinical manifestations. Moreover, knowledge of the variations in the foramina would guide clinicians towards a correct interpretation of radiographs and would be of help in surgical approaches in this complicated region.
METHODS AND MATERIAL: In our study, 64 dry adult skulls were used which were obtained from the Anatomy department and Forensic Department of Saveetha Medical College, Thandalam, Chennai. All skulls used were of same native origin. Damaged skulls were omitted from the study. Vernier Caliper was used to measure the diameters of the foramina. Each dimension was measured thrice and the mean figure recorded. The foramina were measured by its long axis and the short axis. The distance from the midline of the skull to various foramina and from petrous apex to the various foramina was measured. Also, the distance between the right and left foramina were also measured. In case of any significance, such as the foramen being absent was also noted.
Statistical Analysis: The final result has been presented in the form of a mean and standard deviation taking into consideration all the possibilities. The obtained data has been presented in tabular form. Comparisons have been made by measuring the various foramina on the right and left sides of the middle cranial fossa along with the distance between them in a single skull. Significance of the values was considered by taking multiple measurements, cross checking, and the large number of skulls measured. The results were compared with those of similar records in available literature. Photographs of any special variations in the foramina were taken for documentation.
RESULTS: After compiling the observations and using SPSS software, the following results were obtained, which were arranged in tabular form. Results show comparison of mean and standard deviation of maximum dimensions of right and left sided foramina of middle cranial fossa. No statistically significant differences between sides were observed except carotid canal.
Foramen Ovale: In the present study we observed foramen ovale was bilaterally present in all skulls. Its dimensions were arranged in tabular form. Most of the foramen ovale were oval in shape in 2 skulls the shape was circular and the dimentions were tabulated (Table 1). We also observed abnormal findings in one skull which showed the right sided foramen ovale having a thin bony septation perpendicular to the long (i.e. medio-lateral) axis of the foramen. A bony bar which divided it into two compartments was more clearly visible even from the base of the skull. This bony septum divided the foramen into two compartments of approximately equal size. This septation was intrinsic to the foramen and not a part of any ossified ligament (Fig. 1). In another skull, a completely ossified pterygospinous ligament (Fig. 2) passed immediately inferior to the left-sided foramen ovale, effectively leading the exocranial orifice of the foramen to be divided into two bony compartments. Other metrical data of the foramen ovale are presented in Table 1.
Metrical Data on the Foramina Ovale:
TABLE 1: MEAN LENGTH, WIDTH AND RANGE OF FORAMEN OVALE
Foramen
ovale |
Length (mm) | Width (mm) | Range (mm) | |||
Right | Left | Right | Left | M-L diameter | A-P diameter | |
Mean diameter | 7.45 | 7.61 | 3.99 | 4.6 | 3.54-9.21 | 3.33-10.12 |
Standard deviation | 1.1 | 1.15 | 1.8 | 1.4 | - | - |
M-L=Medio-lateral, A-P=Antero-posterior
FIG. 1: THE BELOW ARROW SHOWS BONY SEPTA DIVIDING THE FORAMEN OVALE INTO TWO EQUAL PART
FIG. 2: THE ARROW POINTS TO THE OSSIFIED PTERYGOSPINOUS LIGAMENT
The Foramen Spinosum: The foramen spinosum was present bilaterally in 90% of the skulls studied. However, in one out of the 64 skulls we noticed bilateral absence of this foramen (Fig. 3) and in one skull on its left side it was pin-holed and irregular in shape with duplication (Fig. 4) from which measurement was not taken. Measured values are tabulated (Table 2).
Metrical Data on the Foramina Spinosum:
TABLE 2: MEAN DIAMETER OF FORAMEN SPINOSUM ON RIGHT AND LEFT SIDE
Foramen
spinosum |
M-L axis (mm) | |
Right | Left | |
Mean diameter | 2.54 | 1.97 |
Standard deviation | 0.8 | 0.7 |
M-L = Medio-lateral.
FIG. 3: THE BELOW RIGHT ARROW INDICATES THE ABSENCE OF FORAMEN SPINOSUM, PROBE INDICATES PRESENCE OF FORAMEN SPINOSUM ON THE RIGHT SIDE. (FS-FORAMEN SPINOSUM, FO- FORAMEN OVALE)
FIG. 4: BLUE ARROW INDICATES BONY SEPTUM DIVIDING THE FORAMEN SPINOSUM, RED ARROW INDICATES DUPLICATION OF FORAMEN SPINOSUM
Carotid Canal: The size and dominance (in terms of size) of the carotid canal are significant due to important contents passing through it. The dimensions of the canal in the present study were found to vary between right and left side with significant statistical significance (Table 3).
The mean dimensions of both diameters were marginally higher on the right side but length of the carotid canal was slightly higher in left side than the right side (Direct bone method). Metrical data on the carotid canal are shown in Table 3.
Metrical Data on the Carotid Canal:
TABLE 3: MEAN DIAMETER, LENGTH AND RANGE OF CAROTID CANAL ON RIGHT AND LEFT SIDES
Carotid
canal |
M-L axis (mm) | A-P axis (mm) | Length | Range (mm) | ||||
Right | Left | Right | Left | Right | Left | M-L diameter | A-P axis diameter | |
Mean diameter | 7.3 | 5.9 | 6.08 | 5.36 | 20.3 | 21.03 | 4.92-9.21 | 3.24-7.89 |
Standard deviation | 1.3 | 1.5 | 1.0 | 1.4 | 2.8 | 2.09 | - | - |
M-L = Medio-lateral, A-P = Antero-posterior
Foramen Rotundum: In this study we observed various parameters of foramen rotundum and the finding showed that distance from the midline on the right side was less than the left side (Table 4).
Metrical data on the Foramina Rotundum:
TABLE 4: MEAN DIAMETER AND DISTANCE FROM MIDLINE AND PETROUS APEX TO FORAMEN ROTUNDUM
Parameters | Right (mm) | Left (mm) |
Longituidinal diameter | 4.01 | 4.56 |
Transverse diameter | 3.74 | 3.96 |
Distance from midline | 16.67 | 18.53 |
Distance from petrous apex | 19.01 | 17.02 |
Foramen of Vesalius: Foramen Vesalius is one of the inconsistent foramen of the skull. In this present study this foramen was present in 10 (25%) among 40 skulls observed (Fig. 5). Among the 10 skulls 1 showed asymmetrical duplicated foramen. The foramen of vesalius was present bilaterally in 7 skulls and unilaterally in 3 skulls with the mean diameter about 1.34mm on right side and 1.98mm on left side.
Optic Canal: The measured mean longituidinal and transverse diameters optic canal were 5.21mm, 4.64mm.
Foramen Lacerum: Present study observed bilateral presence of this foramen in all the 64 skulls (Table 5).
FIG. 5: WHITE ARROW INDICATES UNILATERAL PRESENCE OF LEFT FORAMEN VESALIUS LOCATED MEDIAL TO THE DUPLICATED FORAMEN OVALE ORANGE ARROW GREEN ARROW INDICATES FORAMEN SPINOSUM
Metrical Data on the Foramina Lacerum:
TABLE 5: MEAN DIAMETER AND RANGE OF FORAMEN LACERUM ON RIGHT AND LEFT SIDE
Foramen
lacerum |
M-L axis (mm) | A-P axis (mm) | Range (mm) | |||
Right | Left | Right | Left | M-L diameter | A-P axis diameter | |
Mean diameter | 5.21 | 4.9 | 9.73 | 9.1 | 3.2-14.9 | 4.2-12.82 |
Other parameters observed in this study were mentioned in the Table 6 - 9.
Distance from Mid Sagittal Plane to Various Foramina:
TABLE 6: DISTANCE FROM MIDLINE TO FORAMEN OVALE, SPINOSUM AND CAROTID CANAL
Foramen | Right (mm) | Left (mm) |
Ovale | 22.02 | 21.88 |
Spinosum | 27.8 | 26.92 |
Carotid canal | 24.04 | 24.52 |
Distance from Petrous Apex to Various Foramina:
TABLE 7: DISTANCE FROM PETROUS APEX TO FORAMEN OVALE, SPINOSUM AND CAROTID CANAL
Foramen | Right (mm) | Left (mm) |
Ovale | 8.4 | 9.4 |
Spinosum | 9.7 | 11.6 |
Carotid canal | 15.75 | 15.17 |
Distance between Right and Left Foramina:
TABLE 8: DISTANCE BETWEEN VARIOUS RIGHT AND LEFT FORAMINA
Foramen | Distance between right and left foramina (mm) |
Ovale | 44.29 |
Spinosum | 54.56 |
Carotid canal | 48.54 |
Percentage of Various Foramina:
TABLE 9: VARIATIONS OF VARIOUS FORAMINA / CANAL
Foramen / Canal | Unilateral | Bilateral | Absence |
Pterygoid canal | - | 60 (4 broken) | - |
Canaliculus innominatus | 4 (6.25%) | 27 (42.18%) | 33 (51.56%) |
Mastoid canaliculus | - | 64 | - |
Tympanic canaliculus | - | 64 | - |
DISCUSSION: Information regarding normal variations in their shapes, sizes and situation of foramina in the skull gives insight into associations between neurovascular anatomy and the cranial morphology. The sphenoid bone, due to its complex structure and intricate embryological origin, it should be studied in different anatomical aspects, including its normal and abnormal variation. As foramen ovale is one of the important foramens that lie between intracranial and extracranial structures, it is used for diagnostic and therapeutic invasive approaches 3, 4, 5, such as electroencephalographic analysis of seizure for patients undergoing selective amygdalohippo-campectomy, microvascular decompression by percutaneous trigeminal rhizotomy for trigeminal neuralgia and percutaneous biopsy of cavernous sinus tumors 6 etc. For this reason, the knowledge of morphologic and topographic features of foramen ovale is important.
In our present study we observed the presence of this foramen bilaterally in all the skulls. The mean length of the foramen on right side was 7.45 + 1.1 (with the range from 3.54 - 9.21mm) and left side was 7.61 + 1.15 (with the range from 3.33 -10.12mm, Table 10). Just as in earlier studies there was no statistical significance (P > 0.05) between the two sides 3, 5. In this study, the mean width of the FO was 3.99 mm on right side and 4.6mm on left side, According to previous studies, average width of FO in adult skulls was 3.7 mm 7, whereas it was 3.21 ± 0.02 mm and 3.29 ± 0.85 mm on right side and left sides respectively 3.
There are different results in the literature which evaluate the diameters of foramen ovale in different races. The average maximal length of FO was reported as 7.48mm in a developmental study performed in 220 specimens of Japanes race 5, 7.2mm in a German study 9 and 7.46mm in a study performed in Nepal 3, 7.05mm in Indian population 10.
In this present study an average distance of foramen to the midline was similar on both sides (22.02mm on the right side, 21.88mm on the left side). We observed asymmetry in shape (round versus oval) in 21.5% of skulls. To our knowledge, complete absence of the foramen ovale has not been described.
We also observed abnormal findings in one skull which showed the right sided foramen ovale having a thin bony septation perpendicular to the long (i.e. medio-lateral) axis of the foramen which was intrinsically dividing the foramen into two compartments of approximately equal size this bony obstructions could interfere with transcutaneous needle placement into the foramen ovale or distort anatomic relationships during approaches to the cranial base 30 similarly, Ray et al., 3. In their study on anatomic variations of foramen ovale also reported a spine on the margin of the oval foramen in 3 cases, (2 left, 1 right) and 2 sides (1 left, 1 right) sides they found a bridge like bony spur dividing the foramen ovale into two compartments. In the present study we found that the presence of completely ossified pterygospinous ligament may form a foramen, through which the branches of mandibular nerve may pass. Presence of such anomalies may compress upon the branches of the mandibular nerve and chorda tympani nerve. Increase in the width and flattening of the lateral pterygoid plate may leave little space, causing difficulty while performing surgery on the pterygoid region. Anomalies involving the pterygospinous ligament may not only be of academic interest but also be beneficial for maxillofacial and dental surgeons and anesthetists 7.
Comparison of Measurements of Foramen Ovale with Previous Studies:
TABLE 10: FORAMEN OVALE: COMPARISON OF DATA FROM THE PRESENT STUDY WITH THE PREVIOUS STUDIES
Authors | Length | Width | Distsnce from mid sagital line | Distance from apex of petrous | ||
Right | left | right | Left | |||
Lindblom 1936 | 7 | 4 | - | - | - | |
Lang (1983) | 7.26 | 3.65 | - | - | - | - |
Ray et al., | 7.46 | - | - | - | - | -- |
Landl MK, (2005) | 6.6
6.77 |
- | - | - | - | - |
Berge and Bergman (2001) | 7.11 | 3.60 | - | - | - | - |
Osunwoke E.A et al., (2005) | Max-9.5mm
Min-5.0mm |
Max-5
Min-2 |
- | - | - | - |
Namita A. Sharma et al., (2011) | 7.05 | 3.99 | 22.13 | 21.71 | - | - |
M.S. Somesh et al., (2011) | 7.6 | 5.12 | - | -- | - | - |
Unver Dogan, N. et al., (2014) | Rt-7.18 | 7.29 | 22.58 | 22.15 | 9.22 | 9.91 |
Lt-7.29 | 4.06 | |||||
Present study | Rt-7.45 | 3.99 | 22.02 | 21.88 | 8.21 | 8.96
|
Lt-7.61 | 4.6 |
The foramen spinosum is situated postero-lateral to foramen ovale (90% in this study), along the posteromedial aspect of the greater wing of the sphenoid bone. Foramen spinosum of the 40 dry human skulls studied were of varying shapes. Some were either oval or circular. In the present study foramen spinosum was absent in 2% of skull (Tables 2). It is unilaterally absent in 0.4 – 1% of cases 12 - 15 rarely absent on both sides 16, and can be duplicated 17 - 19.
These variations may be important for the vascular supply of the dura as the middle meningeal artery in these cases may enter through the foramen ovale, or through the superior orbital fissure as a branch of the sphenomaxillary portion of the maxillary artery 20. The middle meningeal artery can also arise from the ophthalmic artery, lacrimal artery, or from the petrous (stapedial origin), cavernous, or supraclinoid portion of the internal carotid artery 20, 16. An additional explanation for the absence of a foramen spinosum in the case of an aberrant middle meningeal artery may be when it arises from the stapedial branch of the internal carotid artery or the ophthalmic artery 21.
Duplication can be explained by early division of the middle meningeal artery into a posterior and anterior division resulting in a duplicate FS 21, 4, 22. But there was no explanation on the course of the meningeal branch of the mandibular nerve in the absence or duplication of a FS. The external diameters of FS varied from side to side but did not usually exceed 3mm (Table 2). According to Sondheimer 22, in the instance of the diameter exceeding 5mm; the patient should be immediately evaluated for middle meningeal artery abnormality. This study has revealed that the mean M-L diameter of foramen spinosum was 2.54 + 0.8 on right side, 1.97 + 0.7 on left side, these findings were compared with the previous studies and values are mentioned in the Table 11.
Comparison of Measurements of Carotid Canal with Previous Studies:
TABLE 11: COMPARISON OF MEASUREMENTS OF CAROTID CANAL WITH PREVIOUS STUDIES
Diameter | Berge and Bergman (2001) | Namita A. Sharma
et al., (2011) |
Vidya
et al., (2015) |
Present
study |
Average size (mm)
|
7.13x5.29
|
7.01x5.42 | Rt- 8.12+0.99
6.31+0.64 Lt-8.15+1.00 6.19+0.80 |
Rt-7.3+1.3
5.9+1.5 Lt-6.08+1.0 5.36+1.4 |
Max.size (mm) | 12x5 | 8.7x8.14 | - | 9.21x7.81 |
Min. size(mm) | 5.5x0.64 | 7.14x3.20 | - | 4.9x3.2 |
Distance from mid- sagital plane | - | 25.312 (right)
24.88 (left) |
-
|
24.04 (right)
24.52 (left) |
Distance from petrous apex | - | - | -
|
15.75 (right)
15.17 (left) |
The foramen venosum (Vesalius) is regarded as a small opening in the medial aspect of the greater wing of the sphenoid bone antero-medial to FO. It is interesting to note that the foramen of Vesalius is an exclusive feature of the human skull and is not present in any other primate 23.
We observed presence of single and duplication of this foramen. This foramen was present bilaterally in 17.5% skulls however unilaterally in 7.5% of skulls. In the absence of the FV, the respective emissary vein leaves the skull through the FO (Henderson). In addition, Lang 9 et al., described a small nerve, the nervoulus sphenoidalis lateralis, which may also pass through the FV into the cavernous sinus. The external diameter was found to be 1.34mm on right side and 1.98mm on left side. Which was compared with the values recorded in earlier studies?
Ozer and Govsa 24 explained that the FV presenting with a diameter of less than 0.5mm are most reliable and safe during percutaneous practice as apertures of greater than 0.5mm has a major risk on the adjacent foramen ovale. Surgical importance of foramen vesalius in the fact that during percutaneous trigeminal rhizotomy, needle insertion through the FV the cavernous sinus puncture may occur and has been described in eight cases with temporal lobe hematoma 3.
Therefore, the knowledge about the symmetry and incidence of FV is not only important from the anatomical point of view but is also essential for the operating surgeon. In view of carotid canal contents the dimensions of the carotid canal were important. In the present study values were compared with the previous studies (Table 11). The position, dimensions and extensions of the carotid canal are of vital importance in cases of skull base surgery as in the identification and isolation of the internal carotid artery throughout its petrous course 26. However, the variations in the size of the foramen were more divergent in the study conducted by Berge and Bergman 12.
In another study conducted by Namitha A, noticed bilateral absence of the carotid canal. The canal will fail to develop in the case of agenesis of the ICA, or if the vessel takes an aberrant path 26. The foramen rotundum is situated along the medial root of the greater wing of the sphenoid bone, just lateral to the inferior aspect of the superior orbital fissure and separated from it by a thin bar of bone.
A more common variant of the FR is known as “lateral rotundal canal” with average diameter about 1 to 3mm in the floor of this foramen, which opens in to the infratemporal fossa or in to the space between the pterygoid plates. In anatomic dissections, Sondheimer detected these openings in five of 50 skulls and speculated that they transmitted emissary veins 27. Kocaogullar 28 reported that the average diameter of this foramen was 3.11 in cadaver specimens, 3.44 in 52 skulls. Unver dogan, N. et al., found that there wasn’t statistical significance (P> 0.05) between both sides in the average longitudinal diameters (4.48 ± 1.15mm in the right, 4.36 ± 0.66mm in the left) and average transverse diameters.
This investigation also took up the optic canal also to measure its diameter. The Mean longituidinal and transverse diameters were 5.21, 4.64 (in mm). Duplication and absence of canal was not found in this study.
This canal is an important channel between orbital and intracranial fossa 17. And it is the narrowest path which leads optic nerve to the brain along with ophthalmic artery. Anatomy of the optic canal is important for the surgeons while performing optic nerve decompression surgery 19. Duplications of optic canals have been reported earlier by Warwick, Choudhary et al., and Mandavi Singh. The artery and nerve are separated by a layer of dense connective tissue which may occasionally be ossified to result in the duplication of the optic canal. Probably because it does not transmit any major structure, the foramen lacerum has not been much studied by previous researchers.
In the present study its dimensions were seen to vary between rights and left the values are mentioned in the Table 5. The canaliculus innominatus (also known as the canal of Arnold) is a very small canal situated medially between the foramen ovale and the foramen spinosum 22, 29.
When present, this canal transmits the lesser superficial petrosal nerve, a tiny nerve originating from the tympanic branch of the glossopharyngeal nerve but also containing several fibers from the facial nerve 29.
In the present investigation it was found to be present unilaterally in 4 (6.25%) skulls, bilaterally in 27 (42.18%) skulls and absent in 31 skulls 33 (51.56%). To our knowledge we observed presence or absence of pterygoid canal, tympanic and mastoid canaliculi in all the skulls included in the study.
Anatomical variations in appearance of shape, diameter and distance from mid - sagittal plane, petrous apex to various foramina like foramen ovale, foramen spinosum, foramen vasalius, are of great surgical importance. Knowledge about structures passing through the various foramina of the skull will help in distinguishing normal from potentially abnormal foramina during radiological investigation.
CONCLUSION: The information provided in with this study can help the anatomist to increase the knowledge about anatomy of middle cranial fossa and also help the medical practitioners, in cases of trigeminal neuralgia and in diagnostic detection of tumors and abnormal bony outgrowths that may lead to ischemia, necrosis .
ACKNOWLEDGEMENT: We thank to Saveetha Medical College and Hospital for providing resource material for this study and we also like to thank Dr. Gunapriya Raghunath for constant support and motivation.
CONFLICT OF INTEREST: There are no conflicts of interest between the authors.
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Sankaran PK, Raghunath G, Arathala R, Karthikeyan, Menaka, Madhumitha, Yuvaraj M and Kumaresan M: Morphological study of middle cranial fossa and its variations. Int J Pharm Sci Res 2018; 9(2): 693-01.doi: 10.13040/IJPSR.0975-8232.9(2).693-01.
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Article Information
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693-701
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English
IJPSR
P. K. Sankaran*, G. Raghunath, R. Arathala, Karthikeyan, Menaka, Madhumitha, M. Yuvaraj and M. Kumaresan
Department of Anatomy, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
drpks@live.com
11 May, 2017
02 August, 2017
11 August, 2017
10.13040/IJPSR.0975-8232.9(2).693-01
01 February, 2018