NANOCRYSTALS FOR IMPROVED DRUG DELIVERY: A REVIEW
AbstractNanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce particle size that increases surface area and hence dissolution. Nanoscience technology results in improving solubility, bioavailability and dissolution rate of poorly water-soluble drugs. According to the Noyes-Whitney equation, there is a direct relationship between dissolution rate and surface area of drug particles. Various methods of preparation nanocrystals are Crystallization method, Anti-solvent crystallization, High gravity-controlled precipitation. Evaluation of nanocrystals with different parameters.
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