NEUROPROTECTIVE POTENTIAL OF CINNAMON: EVIDENCE FROM ANIMAL MODELS, MECHANISTIC INSIGHTS, AND THERAPEUTIC IMPLICATIONS
AbstractOwing to the abundant evidence in preclinical models, Cinnamon, and its bioactive constituents are being explored currently for their preventative and therapeutic potential against select neurodegenerative conditions. Cinnamon contains a wide variety of bioactive components viz., cinnamaldehyde, eugenol, cinnamic acid, tannin, catechin, proanthocyanidin, monoterpenes, sesquiterpenes, and coumarin. Cinnamon bark powder, its various extracts and selected components have shown promising results in numerous in-vitro and in-vivo preclinical models. Its efficacy as an antioxidant, anti-inflammatory, and cognitive enhancing properties, and its propensity to modulate several key biochemical and molecular targets in AD, PD, and TBI models has raised considerable interest among researchers who strongly advocate the use of natural compounds to delay /prevent the progression of neurodegenerative conditions. The present review aims to discuss the status of the current data related to the therapeutic propensity of Cinnamon and its derivatives and highlights the need for well-designed clinical trials.
Article Information
7
472-486
771 KB
8
English
IJPSR
Vismaya *, P. S. Rajini and M. Muralidhara
Department of Biochemistry, Bangalore City University, Central College Campus, Bangalore, Karnataka, India.
vismaya4567@gmail.com
11 August 2025
10 October 2025
26 October 2025
10.13040/IJPSR.0975-8232.17(2).472-86
01 February 2026
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