OCULAR DRUG DELIVERY: A REVIEWAbstract
The route of choice for the treatment of ophthalmic diseases is by the topical route because of the blood ocular barrier. The most commonly utilized conventional preparations of ophthalmic dosage forms are the solutions, suspensions and ointments which are relatively inefficient as therapeutic systems. Following administration, a large proportion of the topically applied drug is immediately diluted in the tear film and excess fluid spills over the lid margin and the remainder is rapidly drained into the nasolacrimal duct so required amount of drug is not available for immediate therapeutic action since it binds to the surrounding extra orbital tissues. In view of these losses, frequent topical administration is necessary to maintain adequate drug levels. Systemic administration of a drug to treat ocular disease would require a high concentration of circulating drug in the plasma to achieve therapeutic levels. By using prolonged drug delivery, the duration of drug action can be remarkably prolonged and also the frequency of drug administration can be reduced. Such a drug delivery can be achieved by designing formulations such as microspheres, nanoparticles, liposomes which can act as efficient ocular drug delivery system.
Palani S*, Nisha Mary Joseph, Goda C. C., Anish Zachariah and Zelalem Ayenew
Faculty of Pharmacy, 7th October University, Misurata, Libya
4 January, 2010
23 February, 2010
26 February, 2010
01 March, 2010