OLIBANUM RESIN BASED AMBROXOL HYDROCHLORIDE TABLETS: FABRICATION AND IN VITRO EVALUATION

Present era meant for utilization of natural resources in the development of dosage forms. In the present investigation natural biodegradable polymer olibanum resin is employed to develop matrix tablets of ambroxol hydrochloride for sustained release. Various Ratios of resins is study its ability to retard the early release of the drug from formulation. The tablets were prepared by wet granulation technique and were subjected for their thickness, weight variation test, drug content, hardness and friability. The in vitro dissolution studies were carried out using USP apparatus type II (paddle) at 100 rpm. Drug content of the formulations ranged between 97.78±0.08 to 100.12, where as hardness varies from 5.9-7.6kg/cm². From the in vitro release studies it was found that F5 formulation was similar to marketed sample hence it was selected as a optimized formulation. Higuchi release  kinetics shows r²=0.9298, from Korsemeyer- Peppas plot n value >0.89 indicates super case II type of release indicating that the drug release from these formulations is by erosion of polymer. The optimized formulation of Ambroxol hydrochloride matrix tablets (10%w/w) were subjected to short term stability studies at 45°C with 75% RH for 45 days revealed that no significant differences in physical appearance, drug content, dissolution, T₅₀ and T₉₀ were found