OPTIMISATION AND EVALUATION OF CAFFEINE ORALLY DISSOLVING FILMS
AbstractCaffeine anhydrous is used as a stimulant to improve individual alertness and mental focus due to its ability of inhibiting the function of phosphodiesterase enzyme in the cells. Recent studies also discovered where caffeine reduced the risk of Parkinson’s disease by its inhibitory action on adenosine receptor. With the aim of masking the bitter taste of caffeine, increasing the compliance and convenience in elderly patients, and achieving better therapeutic purpose, the orally dissolving films (ODFs) were developed in this research. Six formulation of caffeine ODFs (CA1-CA6) with increasing caffeine concentrations, 5, 10, 15, 20, 25 and 30% w/v; were prepared by solvent casting method. All of the caffeine ODFs, CA1-CA5 (except CA6), exhibit good film forming capacity and were peelable. The in-vitro disintegration time for CA1-CA5 were in the range of United States Pharmacopoeia’s (USP) criteria (5-30s) and their surface pH is ~7, which suggested administration of ODF is not expected to cause irritation and discomfort.
Article Information
16
5247-5252
894 KB
540
English
IJPSR
S. X. Chong * and S. M. Loong
Faculty of Pharmacy, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.
chongshuxian@segi.edu.my
09 March 2023
09 May 2023
19 June 2023
10.13040/IJPSR.0975-8232.14(11).5247-52
01 November 2023
Download