ORAL EXTENDED RELEASE DRY SUSPENSION OF PARACETAMOL LOADED MICROSPHERESAbstract
Background: A novel reconstitutable suspension of Paracetamol loaded microspheres was prepared using ethyl cellulose as a release controlling polymer and by solvent evaporation technique for the relief of osteo-arthritic pain. Objective: The formulation was developed to enhance patient compliance of population suffering from dysphagia or have difficulty in swallowing oral solid dosage forms like tablets and capsules. Method: Microspheres were evaluated for percent yield, drug loading, and entrapment efficiency, in vitro drug release profile and particle size. The microspheres were formulated as a dry oral suspension which has to be reconstituted at the time of use. Result: The particle size of microspheres was in the range of 550 -700 μm. The entrapment efficiency was in the range of 82.95- 95.56% and the yield obtained was 91.13-98.76%. The dissolution studies of selected trial showed a percent cumulative drug release of not less than 85% at the end of 3 hours. Formulation trial P5containing 4% xanthan gum, 5% purified talc and 6 mg sucralose gave a suspension having good flow property, viscosity, sedimentation value, redispersibility and palatability. The dissolution studies showed a 92.43% cumulative drug release in 3 hours. Comparative dissolution profile with marketed preparation gave a similarity factor of 78. Conclusion: The objective of developing a novel patient-compliant oral suspension for patients having difficulty in swallowing solid dosage forms was achieved.
Anuradha R. Mhadgut * and Vivek V. Nalawade
VES College of Pharmacy, Hashu Advani Memorial Complex, Behind Collector Colony, Chembur (E), Mumbai, Maharashtra, India.
17 December, 2016
03 May, 2017
16 May, 2017
01 July, 2017