OVERVIEW OF SOLID LIPID NANOPARTICLES FOR IMPROVED ANTI-CANCER DRUG DELIVERY
AbstractNanoparticles with lipids as a constituent are called “solid lipid nanoparticles” (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aids in the solubilization of lipophilic compounds. The evolution of multidrug resistance therapy against various chemotherapeutic agents, tissue toxicity, and a high prevalence of drug-resistant tumors are the most common impediments in the clinical management of cancer. For more than a decade, SLNs have been widely used as drug delivery systems in the treatment of various cancers due to their low toxicity, high drug bioavailability, and usefulness with hydrophilic and lipophilic drugs. In this review, we discussed the incorporation and controlled delivery of different cytotoxic anti-cancer drugs to target sites using SLNs to treat various malignancies.
Article Information
09
80-89
790 KB
366
English
IJPSR
Gajendra Prasad Pradhan and Snehamayee Mohapatra *
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India.
snehamayeemohanpatra@soa.ac.in
26 April 2022
04 June 2022
20 June 2022
10.13040/IJPSR.0975-8232.14(1).80-89
01 January 2023
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