OXIDATION OF TRICYCLIC ANTIDEPRESSANT AGENT, AMITRIPTYLINE, BY PERMANGANATE IN SULPHURIC ACID MEDIUM: KINETIC AND MECHANISTIC APPROACH
AbstractThe kinetics of oxidation of amitriptyline by potassium permanganate in aqueous sulphuric acid medium at 298K and at a constant ionic strength of 0.20 mol dm-3 has been investigated spectrophotometrically. The reaction exhibits 5:4 stoichiometry (5 Amitriptyline:4 KMnO4). The reaction was first order with respect to manganese(VII) concentration. The order with respect to amitriptyline was found to be less than unity (0.80). Increase in acid concentration increased the rate. The order with respect to acid concentration was also less than unity (0.40). The effect of added products, ionic strength and dielectric constant has been studied on the rate of reaction. The oxidation products were identified by using 2, 4 DNP derivative, IR, GCMS spectral studies. A suitable mechanism was proposed on the basis of experimental results. The reaction constants involved in the different steps of the reaction mechanism were calculated. The activation parameters with respect to slow step of the mechanism was determined and discussed
Article Information
42
4856-4865
716KB
1358
English
Ijpsr
K. G. Pujeri S. D. Lamani and S.T. Nandibewoor*
P.G. Department of Studies in Chemistry, Karnatak University, Dharwad-580 003, India
stnandibewoor@yahoo.com
20 August, 2012
26 October, 2012
25 November, 2012
42. http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).4856-65
01 December, 2012
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