OXIDATIVE SPECTROPHOTOMETRIC ESTIMATION OF DRUGS USING KMnO4 AND METHYL ORANGE AS DYE
AbstractSimple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Esmolol hydrochloride (ESM), Ramipril (RAM), Gemifloxacin (GEM), Terazosin (TRZ) and Moxifloxacin (MOX), based on their reactivity towards KMnO4. Beer’s law is obeyed in the concentration of 4-28, 4-28, 2.6-18.2, 1.5-10.5 and 1-7 μg ml-1 for Esmolol hydrochloride, Ramipril, Gemifloxacin, Terazosin and Moxifloxacin. The methods involve the addition of excess KMnO4 of known concentration in the presence of 2M H2SO4, reactants are allowed to react and the unreacted KMnO4 is estimated with a fixed amount of Methyl Orange by measuring the absorbance at 507nm. Results of analyses were validated statistically. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. These methods have been applied for the determination of drugs in their pure form as well as in tablet formulations. These methods have been validated in terms of guidelines of ICH
Article Information
20
174-180
472
1500
English
IJPSR
Tirupathi Baddenapalli and Venkateshwarlu Gandu*
Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.
venkateshwarlugoud@yahoo.com
29 June, 2015
20 August, 2015
06 November, 2015
10.13040/IJPSR.0975-8232.7(1).174-80
01 January, 2016
Download