OXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES
HTML Full TextOXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES
Vikas Bhosale 1, Kulbhushan Sasane 1, Dinesh Sasane 2, Valmik Kapase 2 and Limbraj Patil * 2
Department of Chemistry 2, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigondha - 413701, Maharashtra, India.
Department of Chemistry 1, Dada Patil Mahavidyalaya, Karjat - 414402, Maharashtra, India.
ABSTRACT: A quick one step, innovative approach for the Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones with the help of Oxone and Iodobenzene reaction system has been developed in aqueous acetonitrile solution. The developed procedure is applicable to several types of substituted 2-aminothiazole derivatives to get the corresponding products. The developed methodology offers mild reaction condition, short reaction time, and moderate to admirable yields. This is one of the most simple and environmentally benign protocols for synthesis of 2-aminothiazole derivatives. When reaction carried out in presence of oxone and Iodobenzene in aq. Acetonitrile solvent system there is formation of active Hypervalent iodine reagent in situ and that reagent is responsible for this conversion but, yield of reaction is less. We go in detailed in Hypervalent reagent study and got some literature in that researcher used catalytic KBr along with oxone and Iodobenzene and there is amplify in activity of Hypervalent iodine reagent because of catalytic amount of potassium bromide. So we decided to use catalytic amount of KBr along with oxone and Iodobenzene reagent and there is increase in yield of desirable product.
Keywords: |
Heterocyclic Compounds, Aminothiazoles, Oxone, Iodobenzene and thiourea, Hypervalent (III) Compounds
INTRODUCTION: Aminothiazoles have been lately identified as a desired structural element that is screened as part of many drug design processes in medicinal chemistry due to their thiourea like properties and tendency to modulate biological targets 1. Aminothiazole and its derivatives have a broad spectrum of medicinal applications such as antitubercular, 2 anti-inflammatory, 3 antiplatelet, 4 antiviral, 5 anticancer, 6 and human lymphatic filarial parasite 7.
Aminothiazole analogs have also been reported as ligands at adenosine receptors, 8 Anticonvulsants 9 and Thiazoles are also showed to exhibit numerous pharmacological activities 10. This heterocyclic core is also reported in many natural products and pharmaceuticals. Various methodologies such as Hantzsch, Cook Heilborn, and Tchernic for the synthesis of aminothiazoles and their derivatives have been reported.
Among these, Hantzsch thiazole synthesis is the Most widely used which involves reaction of α-halo carbonyl compounds with thiourea or thioamides 11. There are very few reports available in which α-halo carbonyl compounds were generated in situ using ketones and reacted with thiourea to form varieties of aminothiazoles 12.
Recently, aminothiazoles derivatives were also synthesized by aqueous NaICl2, 13 carbon tetrabromaide, 14 nanoclay, 15 Nanochitosan 16, Herein, we report the synthesis of aminothiazoles from thiourea and alkyl / aryl ketones in the presence of Oxone and Iodobenzene and catalytic KBr in aqueous acetonitrile solvent at room temperature. For initial study, we took thiourea and acetophenone as the model substrate Scheme 1. The desirable 2-amino-4-(phenyl) 1, 3,-thiazole was formed when 1 eq. of oxone and 1 eq. Iodobenzene in aq. Acetonitrile solvent added 2 eq. thiourea and acetophenone were treated in aqueous acetonitrile solvent system. Further it was observed that in the absence of oxone or Iodobenzene reaction does not proceed. When reaction carried out in presence of oxone and Iodobenzene in aq. Acetonitrile solvent system there is formation of active Hypervalent iodine reagent in situ and that reagent is responsible for this conversion but, yield of reaction is less. We go in detailed in Hypervalent reagent study and got some literature in that researcher used catalytic KBr along with oxone and Iodobenzene and there is amplify in activity of Hypervalent iodine reagent because of catalytic amount of potassium bromide. So we decided to used catalytic amount of KBr along with oxone and Iodobenzene reagent and there is increase in yield of desirable product.
Viktor V. Zhdankin et al., found that active iodine (III) species [i.e. (hydroxy (phenyl) iodonium ion,)] 17 can be inventively generated in solution by treatment of Iodobenzene with oxone in aqueous acetonitrile at room temperature. Oxone and Iodobenzene reaction system is better reagent for this transformation. This reaction was carried out in Acetonitrile / water reaction system which is helpful for cyclisation and formation of 2-aminothiazole formed in reaction. We have used this combination to present methodology.
MATERIALS AND METHODS: Melting points were determined with melting point apparatus using open capillary tubes and are uncorrected. The IR spectra were recorded in KBr pellets on a Nicolet 400D spectrometer and 1H NMR spectra were recorded in CDCl3 with TMS as internal standard on a Bruker spectrometer at 400 MHz. Purity of the compounds was checked by TLC on silica- G plates of 2 mm thickness using n-hexane and ethyl acetate as solvent system. The visualization of spot was carried out in an iodine chamber.
General Experimental Procedure for Synthesis of 2-aminothiazole Derivatives: Mixture of Oxone (614 mg, 2 mmol) and Iodobenzene (408 mg, 2 mmol) in aqueous acetonitrile stirred at room temperature for 10 min, followed by addition of catalytic amount of KBr (59 mg) under stirring at room temperature followed by addition of Acetophenone (1 mmol) and thiourea (2 mmol) under stirring at room temperature. The resultant reaction mixture was stirred at room temperature until the starting material was completely consumed (TLC). The reaction mixture was diluted with CH2Cl and washed successively with 10% sodium bicarbonate (2 × 15 mL), followed by water (2 × 20 mL). The organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtained crude product. The pure product was obtained after silica gel column chromatography (10% EtOAc–Hexane).
SCHEME 1: SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVE
General Experimental Procedure for Synthesis of 2-aminothiazole Derivatives: Mixture of Oxone (614 mg, 2 mmol) and Iodobenzene (408 mg, 2 mmol) in aqueous acetonitrile stirred at room temperature for 10 min, followed by addition of catalytic amount of KBr (59 mg) under stirring at room temperature followed by addition of Acetophenone (1 mmol) and thiourea (2 mmol) under stirring at room temperature. The resultant reaction mixture was stirred at room temperature until the starting material was completely consumed (TLC).
The reaction mixture was diluted with CH2Cl and washed successively with 10% sodium bicarbonate (2 × 15 mL), followed by water (2 × 20 mL). The organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtained crude product. The pure product was obtained after silica gel column chromatography (10% EtOAc–Hexane).
Table 1, Entry 1, (4-phenylthiazol-2-amine), IR (KBr), cm-1: 3325, 3192, 2926, 1616, 1519, 1367 cm-1. 1H NMR (400 MHZ, CDCl3); δ, ppm: 7.77-7.76 (d, j =7.7, 2H), 7.39-7.36 (d, j = 7.4, 2H), 7.30-7.35 (m, 2H), 5.78 (br, s, 2H). Colorless solid.
Table 1, Entry 2, (4-methylthiazol-2-amine), IR (KBr), cm-1: 3225, 3092, 2926, 1616, 1519, 1367 cm-1, 1H NMR (400 MHZ, CDCl3); δ, ppm: 7.67 (d, J = 7.7, 2H), 7.29 (d, J=7.5, 2H), 2.34 (s, 3H), 6.2 (s, 2H).
Table 1, Entry 3, (4-ethylthiazol-2-amine), IR (KBr), cm-1: 3325, 3192, 2926, 1367 cm-1. 1H NMR (400 MHZ, CDCl3); δ, ppm: 1.25 (t, 3H), 3.07 (q, 2H), 6.48 (s, 1H), 6.99 (br, s, 2H).
Table 1, Entry 4, (4-isobutylthiazol-2-amine), IR (KBr), cm-1: 3325, 3192, 2926, 1367 cm-1. 1H NMR (400 MHZ, CDCl3); δ, ppm: 2.28 (s, 3H), 6.48 (s, 1H), 6.99 (s, 2H, NH2).
Table 1, Entry 5, 4-(chloromethyl) thiazol-2-amine, IR (KBr), cm-1: 3325, 3192, 2926, 1616, 1519, 1367 cm-1. 1H NMR (400 MHZ, CDCl3); δ, ppm: 7.56 (d, j = 7.8, 2H), 7.0 (d, j = 7.4, 2H), 6.27 (s, 2H), 7(br s, 2H).
Table 1, Entry 6, 4-(p-tolyl) thiazol-2-amine, IR (KBr), cm-1: 3402, 3240, 1500, 715; 1H NMR (400 MHz, CDCl3); δ, ppm: 6.72 (s, 2H, NH2), 6.76 (s, 1H, thiazole C-H), 7.2-7.6 (m, 4H, Ar C-H), 2.34 (s, 3H, CH3),
Table 1, Entry 7, 4-(4-Hydroxyphenyl) thiazol-2-amine; IR(KBr), cm-1: 3445, 2917, 1615, 1500, 1435, 834; 1H NMR (400 MHz , CDCl3); δ, ppm: 6.67 (d, J = 8.5 Hz, 2H, Ar-H), 6.72 (s, 1H, thiazole), 6.95 (s, 2H, NH2), 7.57 (d, J = 8.5 Hz, 2H, Ar-H), 9.50 (s, OH).
Table 1, Entry 8, 4-(3-Methylphenyl) thiazol-2-amine, IR (KBr), cm-1: 3420, 2915, 1600, 1521, 1458, 714; 1H NMR (400 MHz, CDCl3): δ, ppm: 2.48 (s, 3H, CH3), 6.95 (s, 1H, thiazole), 7.00 (s, 2H, NH2), 7.02 (d, J = 7.8 Hz, 1H, Ar-H), 7.20 (t, 1H, J = 7.9 Hz, Ar-H), 7.52 (d, J = 7.9Hz, 1H, Ar-H), 7.60 (s, 1H, Ar-H).
Table 1, Entry 9, 4-(4-Chlorophenyl) thiazol-2-amine, IR (KBr), cm-1: 3415, 2900, 1620, 1570, 1487, 735; 1H NMR (400 MHz, CDCl3); δ, ppm: 7.22 (1H, S, thiazole C-H), 7.52 (2H, J= 8.4 HZ Ar-H), 7.70 (2H, J = 8.4 H, Ar-H), 8.82 (s, 2H, NH2).
TABLE 1: ALIPHATIC AND AROMATIC KETONES ARE CONVERTED INTO AMINOTHIAZOLES
S. no. | Substrate | Product | Time (min) | Yield % |
1 | ![]() |
![]() |
180 | 87 |
2 | ![]() |
![]() |
190 | 85 |
3 | ![]() |
![]()
|
195 | 82 |
4 | ![]() |
![]() |
195 | 80 |
5 | ![]() |
![]() |
185 | 89 |
6 | ![]() |
![]() |
165 | 85 |
7 | ![]() |
![]() |
160 | 80 |
8 | ![]() |
![]() |
190 | 79 |
9 | ![]() |
![]() |
185 | 87 |
a. Reaction conditions: thiourea 2 eq., ketones 1 eq. and oxone 2 mmol, Iodobenzene 2 mmol and catalytic KBr in aq. Acetonitrile solvent at room temperature.
RESULT AND DISCUSSION: To develop a suitable protocol for formation of 2-aminothiazole, initially the plane acetophenone and thiourea treated with Oxone (2 mmol) and Iodobenzene (2 mmol) in the acetonitrile water solvent system in presence of catalytic amount of KBr at room temperature was chosen as a model reaction as expected product was obtained in exceptional yields in 3 h. Completion of the reaction was monitored by Thin Layer Chromatography (TLC). After completion of reaction, workup carried out as given in experimental procedure, pure product was isolated by column chromatography.
ACKNOWLEDGEMENT: We all are thankful to Dr. Bal Kamble, Principal of Dada Patil Mahavidyalaya, also thankful to DST-FIST for providing funding for central instrument facility.
CONFLICT OF INTEREST: No conflict of interest.
REFERENCES:
- Joshi S, Dixit S, Korat TAUMH and Badiger A: Synthesis, characterization, biological activity, and 3D-QSAR studies on some novel class of pyrrole derivatives as antitubercular agents. Medicinal Chemistry Research 2014; 23: 1123-1147.
- Meissner A, Boshoff H, Vasan M and Benjamin P: Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry 2013; 21: 6385.
- Helal M, Salem M, El-Gaby M and Aljahdali M: Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents: European Journal of Medicinal Chemistry 2013, 65: 517-526.
- Pi Z, Sutton J, Lloyd J, Hua J, Price L, Wu Q, Chang M, Zheng J, Rehfuss R, Huang CS, Wexler RR and Patrick YS: Lam: 2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents. Bioorganic and Medicinal Chemistry Letters 2013; 23: 4206-4209.
- Özbek O, Usta N, Gürdere M, Aslan O, Budak Y and Ceylan M: Synthesis and antibacterial screening of novel 2(4- (aryl) thiazol-2-yl)- 3a, 4, 7, 7a-tetrahydro-1H 4, 7 ethanoisoindole-1,3(2H)-dione derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements 2017; 10: 1153-1157.
- Romagnoli R, Baraldi P, Salvador M, Camacho E, Preti D, Tabrizi M, Bassetto M, Brancale A, Hamel E, Bortolozz R, Basso G and Viola G: Synthesis and biological evaluation of 2-substituted-4-(30, 40, 50 -trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic and Medicinal Chemistry 2012; 20: 7083-7094.
- Sashidhara K, Rao B, Kushwaha V, Modukuri R, Verma R and Murthy: Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi. Bioorganic and Medicinal Chemistry 2014; 14: 473-480.
- Koppireddi S, Chilaka DRK, Avula S, Kotamraju JKS and Yadla R: Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo [2, 1-b]thiazoles. Bioorganic and Medicinal Chemistry Letters 2014; 24: 28-5431
- Alagarsamy A, Senthilraja M and Solomon R: Design and Synthesis of 3-Substituted-thiazolyl-2-iminothiazolidin-4-ones as a New Class of Anticonvulsants. Journal of Heterocyclic Chemistry 2016; 5: 1635-1639.
- Ge L, Hu Q, Shi M, Yang H and Zhu G: Design and discovery of novel thiazole derivatives as potential MMP inhibitors to protect against acute lung injury in sepsis rats via attenuation of inflammation and apoptotic oxidative stress. RSC Advance 2017; 7: 32909-32922.
- Zhu YP, Yuan JJ, Zhao Q, Lian M, Gao QH, Liu MC, Yang Y and Wu AX: I2/CuO-catalyzed tandem cyclisation strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α, β-unsaturated ketones and thiourea. Tetrahedron 2012; 68: 173-178.
- Xue WJ, Zheng KL, Li HZ, Gao FF and Wu AX: Iodine-promoted selective synthesis of substituted aminothiazole via a selfsorting reaction network. Tetrahedron Letters 2014; 55: 4212-4215.
- Ghodse S and Telvekar V: Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl/aryl ketones using aqueous NaICl2. Tetrahedron Letters 2015; 2: 472-474.
- Keshari T, Kapoor R and Lal DL: Carbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: an easy access to 2-aminothiazoles. Tetrahedron Letters 2015; 41: 5623-5627.
- Zarnegar Z, Alizadeh R, Ahmadzadeh M and Safari J: C–N bond formation in alicyclic and heterocyclic compounds by amine-modified nanoclay. Journal of Molecular Structure 2017; 1144: 58-65.
- Safari J, Zarnegar Z, Abedi-Jazini Z and Sadeghi M: Nanochitosan: A biopolymer catalytic system for the synthesis of 2aminothiazoles 2016; 77: 108-112.
- Zhdankin V, Zagulyaeva A, Banek C and Yusubov M: Hofmann Rearrangement of Carboxamides Mediated by Hypervalent Iodine Species Generated in Situ from Iodobenzene and Oxone: Reaction Scope and Limitations. Organic Letters 2010; 12: 4644-4647.
How to cite this article:
Bhosale V, Sasane K, Sasane D, Kapase V and Patil L: Oxone and iodobenzene are useful reaction system for synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones. Int J Pharm Sci & Res 2018; 9(8): 3469-73. doi: 10.13040/IJPSR.0975-8232.9(8).3469-73.
All © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
Article Information
43
3469-3473
364
1054
English
IJPSR
V. Bhosale, K. Sasane, D. Sasane, V. Kapase and L. Patil *
Department of Chemistry, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigondha, Maharashtra, India.
limbrajp@gmail.com
08 November, 2017
24 January, 2018
06 February, 2018
10.13040/IJPSR.0975-8232.9(8).3469-73
01 August, 2018