PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL IN WESTERN ODISHA
HTML Full TextPATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL IN WESTERN ODISHA
Sapan Kumar Behera 1, Bhabagrahi Rath * 2, Sashi Bhusan Biswal 2 and Sabita Mohapatra 2
Department of Clinical Pharmacology 1, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry - 605006, India.
Department of Pharmacology 2, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur - 768017, Odisha, India.
ABSTRACT: Objective: To assess the pattern of adverse drug reactions (ADRs) in a tertiary care hospital. Materials and methods: This study was conducted in VSS Medical College, Burla, Odisha from October 2012 to September 2014. ADRs collected from various clinical departments were compiled and analyzed for distribution of age, gender, department, drug class and organ system. Assessment of causality, severity, and preventability was done using specific scales. Results: The occurrence of ADRs was more in males compared to females in the age group 19-60 years of age. Most of the ADRs were collected from medicine department followed by dermatology and psychiatry. The skin was the most common organ system affected followed by gastrointestinal and central nervous system. Antiretroviral drugs were the most common drugs causing ADRs followed by antimicrobials and antipsychotics. Skin rashes were the most common reaction followed by vomiting and extrapyramidal symptoms (EPS). Causality assessments of ADRs were probable for 35.71 % and possible for 64.29 %. Most of the ADRs were of moderate severity (47.48 %) followed by mild (45.38%) and severe (7.14%). 59.67% of ADRs were categorized as probably preventable whereas 36.47% were not preventable. Conclusions: Majority of ADRs can be prevented by taking proper action at the early stage. Knowledge about the drugs and predictable adverse drug reactions are the requirement for preventing severe adverse drug reactions at a later stage.
Keywords:
|
Adverse Drug Reaction (ADR), Pattern of ADRs, ADR monitoring, Tertiary care hospital
INTRODUCTION: Adverse drug reaction (ADR) is defined as "Any response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of diseases or for the modification of physiological function 1.
ADR is the cause of considerable morbidity and mortality in Europe 2. According to Commission staff document of European communities, approximately 5 % of all hospital admissions are due to ADRs and 5 % of all hospitalized patients develop ADRs during their hospital stay 2. It also constitutes 4th to 6th common cause of death in hospitalized patients 3.
In addition to increasing the duration of hospital stay, ADRs also increase the cost of hospitalization. The overall economic burden of adverse events according to literature ranges from about 0.2% to 6.0% of total health expenditure 4.
The cost for treating a single ADR in US and India is US $ 2500 and Rs. 690 (US $ 15) respectively 5, 6. In the majority of cases, ADRs result due to the extension of the desired pharmacologic effects, substantial variability in pharmacokinetics and pharmacodynamics among patients 7. Various factors responsible for causation of ADRs are a) patient-related factors such as age, gender, body weight with fat distribution, allergy, maternal status, fetal development and creatinine clearance b) social factors like race, ethnicity, alcohol consumption and smoking c) drug-related factors such as polypharmacy, dose and frequency of drugs, off-label use of drugs, self-medication and d) disease-related factors 8 - 10.
With this background, the objective of our study was to detect, analyze and assess various parameters such as causality, severity and preventability of adverse drug reactions occurring in the inpatients as well as the out-patients of a tertiary care hospital in Western Odisha.
MATERIALS AND METHODS: A cross-sectional study was conducted between October 2012 to September 2014 to collect ADRs from various departments of VSS Medical College, Burla, Sambalpur, Odisha. Institutional Ethical Committee (IEC) approval was obtained before undertaking the study. Informed consent was obtained from patients before collecting ADRs for prospective data.
All the data regarding ADR collected in suspected ADR monitoring form (developed by Central Drug Standard Controlling Organization (CDSCO), India) from various departments were analyzed for distribution according to age, gender, department, drug class and organ system affected. Assessment of causality, severity, and preventability were done according to WHO-UMC causality assessment scale 10, Modified Hartwig and Siegel’s severity assessment scale 11 and Modified Schumock and Thronton preventability scale 12 respectively. All the results are expressed in percentage.
RESULTS: A total of 238 ADRs were collected from various departments of VSS Medical College, Burla during the study period (October 2012 to September 2014). The percentage of ADR was highest in the age group 19-60 years (188, 78.99%) followed by 0-18 years (29, 12.18%) and age more than 60 years (21, 8.83%) respectively as depicted in Table 1.
TABLE 1: AGE-WISE DISTRIBUTION OF ADRs
S. no. | Age group | Numbers | Percentage |
1 | 0-18 | 29 | 12.18% |
2 | 19-60 | 188 | 78.99% |
3 | >60 | 21 | 8.83% |
Total | 238 | 100 % |
Total number of ADRs in males (147, 61.77 %) were more compared to females (91, 38.24 %) as shown in Table 2.
TABLE 2: GENDER WISE DISTRIBUTION OF ADRs
S. no. | Sex | Number | Percentage |
1 | Male | 147 | 61.76% |
2 | Female | 91 | 38.24% |
Total | 238 | 100% |
Maximum number of ADRs were reported from medicine department (83, 34.87%) followed by dermatology (47, 19.75%) psychiatry (35, 14.71%) and Anti-retroviral therapy (ART) centre (34, 14.29%) as shown in the Table 3.
TABLE 3: DEPARTMENT WISE DISTRIBUTION OF ADRs
S. no. | Department | No. of ADRs | Percentage |
1 | Medicine | 83 | 34.87% |
2 | Dermatology | 47 | 19.75% |
3 | Psychiatry | 35 | 14.71% |
4 | ART centre | 34 | 14.29% |
5 | Cancer | 30 | 12.60% |
6 | Pulmonary medicine | 05 | 2.10% |
7 | Paediatrics | 02 | 0.84% |
8 | ENT | 01 | 0.42% |
9 | Anaesthesia | 01 | 0.42% |
Total | 238 | 100% |
The skin was found to be the most vulnerable organ, and incidence of cutaneous ADRs (100, 42.02%) was highest followed by gastrointestinal (49, 20.59%), Central Nervous System (CNS) (28, 11.77%) and musculoskeletal (19, 7.98%) as shown in Fig. 1.
ADRs among different class were highest for antiretroviral drugs (46, 19.33%) followed by antimicrobials (36, 15.13%) and antipsychotics (15.13%) as shown in Table 4.
As shown in Table 5, skin rash (61) was the commonest ADR encountered followed by vomiting (25), Extrapyramidal symptoms (EPS) (18) and diarrhea (9). The incidence of other ADRs was few and distributed in different body systems.
FIG. 1: ORGAN SYSTEM WISE DISTRIBUTION OF ADRs
TABLE 4: DISTRIBUTION OF ADRs AMONG DIFFERENT CLASSES OF DRUGS
S. no. | Drug class | Number of ADRs | Percentage of total ADRs |
1 | Antiretroviral | 46 | 19.33% |
2 | Antimicrobials | 36 | 15.13% |
3 | Antipsychotics | 36 | 15.13% |
4 | Anticancer | 32 | 13.45% |
5 | Antiepileptic | 23 | 9.66% |
6 | Antimalarials | 17 | 7.14% |
7 | NSAIDs | 15 | 6.30% |
8 | Antihypertensive | 06 | 2.52% |
9 | Antitubercular | 06 | 2.52% |
10 | Miscellaneous | 21 | 8.82% |
Total | 238 | 100% |
TABLE 5: SYSTEMIC INVOLVEMENT DUE TO ADRs
Organ System | ADR | Number | Organ System | ADR | Number |
Skin | Rash | 61 | Central nervous system | E. P. S. | 18 |
S. J. syndrome | 12 | Tremor | 4 | ||
Dermatitis | 6 | Headache | 2 | ||
Bullous lesion | 5 | Psychosis | 2 | ||
FDE | 2 | Dizziness | 1 | ||
Exfoliative dermatitis | 2 | Convulsion | 1 | ||
ENL | 2 | Anorexia | 1 | ||
Skin discolouration | 2 | Vertigo | 1 | ||
Urticaria | 1 | Hepatic | Hepatitis | 3 | |
Skin peeling | 1 | Hematological | Anemia | 8 | |
Pellagra | 1 | Leucopenia | 2 | ||
Gangrene | 1 | Neutropenia | 1 | ||
Hand foot syndrome | 1 | Immunological | Angioedema | 2 | |
TEN | 1 | Anaphylaxis | 1 | ||
Erythema multiforme | 1 | Red man syndrome | 1 | ||
Gastrointestinal | Vomiting | 25 | Endocrine | Hyperglycemia | 2 |
Diarrhea | 9 | Hypertriglyceridemia | 2 | ||
Malena | 5 | Musculoskeletal | Pedal edema | 4 | |
Abdominal pain | 4 | Weight gain | 2 | ||
Gastritis | 3 | Weight loss | 2 | ||
Constipation | 2 | Rigor | 2 | ||
Nausea | 1 | Periorbital edema | 1 | ||
Hematemesis | 1 | Swelling of leg | 1 | ||
Cardiovascular | Hypotension | 1 | Jaw pain | 1 | |
Arrhythmia | 1 | Myopathy | 1 | ||
Palpitation | 1 | Thrombophlebitis | 1 | ||
Bradycardia | 1 | Neck pain | 1 | ||
Cardiomyopathy | 1 | Lower extremity pain | 1 | ||
Ophthalmology | Photophobia | 2 | Genito-urinary | Urinary retention | 3 |
Conjunctivitis | 1 | Hematuria | 1 | ||
Peripheral nervous system | Peripheral
neuropathy |
3 | Penile
swelling |
1 | |
Respiratory | Cough | 4 | Total | 238 |
EPS: Extrapyramidal symptoms, ENL: Erythema nodosum leporosum, TEN: Toxic epidermal necrolysis, FDE: Fixed drug eruption, SJS: Stevens-johnson syndrome
ADRs encountered with the use of different antiretrovirals drugs were highest for nevirapine (9.66%) followed by zidovudine, stavudine and efavirenz. Out of the total 36 antimicrobials related ADRs, amoxicillin (6, 2.52%) and ceftriaxone (5, 2.10%) were found to be responsible for maximum number of ADRs followed by azithromycin, piperacillin, ofloxacin, cefpodoxime, levofloxacin, doxycycline, chloramphenicol, gentamycin, cefotaxime, ornidazole and vancomycin.
Out of 36 antipsychotic drugs related ADRs, risperidone was responsible highest number of ADRs (9, 3.78%) followed by haloperidol (7, 2.94%) olanzapine (6, 2.52%). Among the anticancer drugs (total 32) 5-FU produced highest percentage (11, 4.62%) ADRs followed by cisplatin (9, 3.78%) and vincristine (5, 2.10%). Out of 23 antiepileptic drugs induced ADRs, phenytoin and carbamazepine produced (8, 3.36%) ADRs each followed by valproate (6, 2.52%) and gabapentin (1, 0.42%).
Of the total 17 antimalarial induced ADRs, Artesunate-Sulfadoxine-Pyrimethamine revealed highest percentage (8, 3.36%) followed by chloroquine (7, 2.94%) and quinine (2, 0.84%). Out of 15 analgesic-related ADRs, diclofenac was responsible for (7, 2.94%) followed by ibuprofen and paracetamol (each 2, 0.84%). The other NSAIDs involved in the production of ADRs were indomethacin and naproxen, piroxicam, aspirin. (3, 1.26%) out of total six (6) antihypertensive induced ADRs were induced by amlodipine and (1, 0.42%) ADR each by ramipril, enalapril and losartan.
The combination of isoniazid and rifampicin was responsible for (4, 1.68%) ADRs whereas rifampicin and pyrazinamide were the cause for (1, 0.42%) ADR out of total 6 ADRs caused due to anti-tubercular drugs.
Out of 21 ADRs induced by the miscellaneous drug, traditional medicine was found to be more prone to development of ADRs (3, 1.26%) followed by antidiabetic, disease modifying antirheumatic drugs (DMARDs), opioids (2, 0.84%). The other drug classes causing ADRs were corticosteroids, bronchodilator, diuretics as well as antiemetic, antihistamine.
According to WHO-UMC scale, causality assessment for ADRs was probable in (85, 35.71%) cases and possible in (151, 64.29%) cases as shown in Fig. 2. All the causality grades belonged to either probable or possible category. None of the ADR belonged to other categories like Certain, Unlikely Conditional/ Unclassified or Unassessable/ Unclassified.
FIG. 2: CAUSALITY ASSESSMENT OF ADRs
Chance of drug involvement in producing the ADRs was probable for 32 cases treated with antipsychotics, 13 cases with anti-epileptics, 6 cases treated with antimalarials, 22 cases taking antimicrobials, 9 cases patients receiving NSAIDs, 2 cases receiving anti-hypertensive. Similarly, drug as the possible cause of ADRs was 44 cases for antiretroviral drugs 30 cases for anticancer, 11 cases for antimalarials, 14 cases for antimicrobials, 6 cases for NSAIDs, 4cases for antihypertensives, 16 cases for antipsychotics. Out of the 238 cases of ADRs encountered, (108, 45.38%) were found to be mild, (113, 47.48%) were moderate and (17, 7.14%) were of severe degree as shown in Fig. 3.
FIG. 3: SEVERITY ASSESSMENT OF ADRs
A severe grade of ADRs was found in 2 cases treated by antimicrobials, 7 cases by antiepileptics, 3 cases by antimalarials, 1 receiving anticancer and 4 cases receiving miscellaneous drugs. ADRs of moderate severity was seen in 23 cases treated with antipsychotics, 20 cases treated with antimicrobials, 12 treated with antiepileptic, 15 taking antiretrovirals, 12 treated with NSAIDs and 10 treated with antimalarials. Mild ADRs were encountered in 31 patients treated with antiretrovirals, 27 patients receiving anticancer, 14 treated with antimicrobials and the occurrence of mild ADRs in antimalarial, antiepileptic and antihypertensive treated patients were 4 cases each.
As shown in Fig. 4, (8, 3.36%) out of 238 ADRs were definitely preventable, (88, 36.97%) were not preventable and (142, 59.67%) ADRs were probably preventable.
FIG. 4: ASSESSMENT OF PREVENTABILITY OF ADRs
The number of definitely preventable ADRs were highest in anti-malarial (4 cases) followed by NSAIDs (2 cases) and (1 case) in both anti-microbial and anti-epileptic treated group. ADRs belonging to not preventable category were 38 with antiretrovirals, 18 with antimicrobials, 9 cases with anticancer and 4 cases with antipsychotics. The probably preventable ADRs were headed by antipsychotics (32 cases) followed by anticancer (23 cases), antiepileptic (21 cases), antimicrobials (17 cases), antimalarials (11 cases), NSAIDs (10 cases) and antiretrovirals (8 cases).
DISCUSSION: A cross-sectional study was conducted for a period of two years (from October 2012 to September 2014) for detection and analysis of adverse drug reactions occurring in OPD and in-patients of diverse disciplines of a tertiary care hospital in Western Odisha.
ADRs collected from various departments such as medicine, pediatric, dermatology, psychiatry, pulmonary medicine and ART Centre were included in the study. Age wise analysis revealed incidence of ADRs was highest in middle age, between19-60 years of age (78.57%) followed by 0-18 years and more than 60 years (Table 1). Our observation is similar to the study done by Bhandare et al., 14 who also reported the maximum percentage of ADRs between the age 19 - 60 years. Lobo et al. found most of the ADRs in the age group 19-60 years followed by more than 60 and 0 - 18 years 15. This may be due to the increased number of the patient attending the hospital for this age group.
The incidence of ADRs was more in males (61.76%) compared to females (38.24%) (Table 2). This finding is similar to the result of the study done by Haile et al., 16 who also reported similar findings that in the male percentage of ADR was (590 out of 1033, 57.12%). Lobo et al., have mentioned a higher incidence of ADRs in males (55.7%) compared to females (44.3%) 15. This gender difference in the occurrence of ADR could be due to the increased number of hospital visit by male patients compared to female patients.
Most of the ADRs were reported from medicine department followed by dermatology psychiatry and ART centre as shown in Table 3. This finding is similar to the result of the study conducted by Rehan et al., 17 who also mentioned most ADRs reported from in-patients and OPD of medicine department. The probable explanation for this could be the higher patient load in medicine department is quite high compared to other departments. Most of the reactions in patients taking antiretroviral drugs are also treated in medicine OPD and in-patients.
The drug classes observed to produce adverse drug reactions in different patients were diverse in nature and headed by antiretrovirals drugs followed by antipsychotics, antimicrobial, anticancer, antiepileptics, miscellaneous group (consisting of steroid, diuretics, prokinetics, bronchodilators, antihistamines, antidiabetics, DMARDs, IV fluid, opioids), antimalarials, NSAIDs, antihypertensives and antituberculars (Table 4). This finding is in contrast to the studies conducted by Gupta et al., 18 who mentioned antimicrobial-related ADRs as highest percentage whereas in our study it was the second highest ADR. This could be due to proper maintenance of ADR records by ART centre, non-reporting or lack of documentation of ADRs by other departments, narrow therapeutic window of antiretrovirals drugs and also in many cases, patients has to continue the antiretroviral medication in spite of the ADR that may increase the chances of ADR to be detected by physicians.
The most common organ system affected in our study was skin followed by gastrointestinal, CNS, musculoskeletal and hematological as shown in the Fig. 1. This is similar to the finding of the study conducted by Lihite et al., 19 who also reported skin as the most commonly affected organ system.
Skin rash was the most common ADR encountered followed by vomiting, EPS, diarrhea as shown in Table 5. The incidence of other ADRs are few in number and distributed in different major body systems. This finding is dissimilar to the finding of Roy et al., 20 who reported anaphylaxis as the most common ADR followed by the maculopapular rash.
Causality Assessment (WHO-UMC Criteria): Causality Assessment of ADRs was done by WHO-UMC scale 7. It was chosen over Naranjo algorithm because it is simple, less time-consuming and widely acceptable. Causality assessment of ADRs found in our study revealed that the chance of drug involvement in producing the different ADRs as probable for 85 cases (35.71%) and possible in 153 cases (64.29%) as shown in Fig. 2. None of the ADRs belonged to any other causality category. This finding is similar to the finding of the study conducted by Rehan et al., 17 who also assessed most ADRs as possible (55%) followed by probable (45%). In another study conducted by Harikrishna et al., reported that causality assessment of 66.17 % and 32.35 % of ADRs were probable and possible respectively 21.
Severity Assessment (Modified Hartwig and Siegel Scale): Severity assessment of ADRs was done by Modified Hartwig and Siegel scale 8. Most of the ADRs were assessed as moderate severity followed by mild and severe as shown in Fig. 3. The finding is similar to the observation of the study conducted by Sivasakthi et al., 22 who also assessed most of the ADRs as moderate followed by mild and severe. The severity assessment in our study revealed, antiepileptics were responsible for most cases of severe ADRs followed by antimalarials, antimicrobials, antipsychotics, antiretrovirals drugs.
Preventability Assessment (Thornton and Schumock scale): 9 In our study, most of the ADRs were assessed probably preventable followed by not preventable and definitely preventable (Fig. 4) which is similar to the results of Tiwari et al.,5 who also assessed most ADRs as probably preventable (95%) followed by definitely preventable (5%). The highest number of ADRs in the probably preventable category reflects a huge scope of improvement in the current prescribing practices.
CONCLUSION: Majority of adverse drug reactions in tertiary care level are preventable. Knowledge about drugs and background patient information can help to prevent easily preventable adverse drug reactions. Healthcare professionals should be aware of adverse effects of drugs at an early stage to prevent severe adverse drug reactions at a late stage.
ACKNOWLEDGEMENT: We are thankful to our pharmacovigilance associate Mr. Pravat and the physicians who have helped for the collection of adverse drug reactions throughout the study period.
CONFLICT OF INTEREST: There are no conflicts of interest.
REFERENCES:
- Passarelli MCG and Filho WJ: Adverse drug reaction in elderly patients: how to predict them? Einstein. 2007; 5: 246-251.
- European Commission: Proposal for a regulation amending, as regards pharmacovigilance of medicinal products for human use. Regulation (EC) No 726/2004.Impact assessment. 2008.http://ec.europa.eu/health/files/pharmacos/pharmpack_12_ 2008/pharmacovigilance-ia-vol1_en.pdf.
- Leape LL, Brenman TA, Laird N, Lawthers AG, Localio AR, Barnes BA, Hebert L, Newhouse JP, Weiler PC and Hiatt H: The nature of adverse events in Hospitalized patient: Result of Harvard Medical practice study II. New Engl. J. Med. 1991; 324: 377-84.
- Costs of unsafe care and cost effectiveness of patient safety programmes. European Union, 2016.https://ec.europa.eu/health/sites/health/files/...performance.../2016_costs_psp_en.pdf.
- Rabbur RSM and Emmerton L: An introduction to adverse drugreaction reporting systems in different countries. Int J Pharm Pract. 2005; 13: 91-100.
- Ramesh M, Pandit J and Parthasarathi G: Adverse drug reactions in a south Indian hospital-their severity and cost involved. Pharmacoepidemiol Drug Saf.2003; 12: 687-92.
- Tiwari P, Anuradha, D’Cruz S and Sachdev A: Adverse drug reaction monitoring in a North Indian public teaching hospital. J Pharma Care Health Sys. 2016; 3: 1-6.
- Alomar MJ: Factors affecting the development of adverse drug reactions. Saudi Pharm J. 2014; 22: 83-94.
- Mason J, Pirmohamed M and Nunn T: Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature. Eur J Clin Pharmacol. 2012; 68(1): 21-8.
- Schmiedl S, Rottenkolber M, Hasford J, Rottenkolber D, Farker K, Drewelow B, Hippius M, Salje K and Thurmann P: Self-medication with over-the-counter and prescribed drugs causing adverse-drug-reaction-related Hospital Admissions: Results of a prospective, long-term multi-centre study. Drug Saf. 2014; 37(4): 225-35.
- The use of the WHO-UMC system for standardized case causality assessment.https://www.who-umc.org/media/2768/standardised-case-causality-assessment.pdf. (Last accessed on 2017 June 9)
- Hartwig SC, Siegel J and Schneider PJ: Preventability and severity assessment in reporting adverse drug reactions. AM J Hosp pharm. 1992; 49: 2229-32.
- Schumock GT and Thornton JP: Focusing on the preventability of adverse drug reactions. Hosp Pharm. 1992; 27: 538.
- Bhandare B, Shabeer D and Satyanarayana V: A study on adverse drug reactions in a tertiary care hospital in Bangalore. IJOPP. 2017; 4: 49-54.
- Lobo MGA de A, Pinheiro SMB, Castro JGD, Momenté VG and Pranchevicius M-CS: Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil. BMC Pharmacology and Toxicology. 2013; 14: 5.
- Haile DB, Ayen WY and Tiwari P: Prevalence and assessment of factors contributing to adverse drug reactions in wards of a tertiary care hospital, india. Ethiop J Health Sci. 2013; 23: 39-48.
- Rehan HS, Chopra D, Sah RK and Mishra R: Adverse drug reactions: Trends in a tertiary care hospital. Curr Drug Saf. 2012; 7: 384-8.
- Gupta A, Kaur A, Shukla P and Chhabra H: Adverse drug reactions pattern in a tertiary level teaching hospital: A Retrospective Study. IJOPP. 2017; 10: 27-31.
- Lihite RJ, Lahkar M, Das S, Hazarika D, Kotni M, Maqbool M, Phukan S: A study on adverse drug reactions in a tertiary care hospital of Northeast India. AJM. 2017; 53: 151-56.
- Roy D, Purkayastha A and Tigga R: Analysis of adverse drug reaction in a tertiary care hospital: a retrospective study. Asian J Pharm Clin Res. 2017; 10: 347-49.
- Harikrishna A, Prasannakumar, Hemanthkumar N, Ch M, Rakanth: Adverse drug reaction monitoring and reporting at H.S.K Hospital and Research Center-Bagalkot. Research & Reviews: Journal of Hospital and Clinical Pharmacy. 2016; 2(2): 54-62.
- Sivasakthi R, Senthil KC, Uday Chander SJ, Sam Solomon WD, Jose S, Venkatanarayanan R: A prospective study of adverse drug reaction monitoring in tertiary care hospital. Am. J. Pharm Health Res. 2015; 3: 58-64.
How to cite this article:
Behera SK, Rath B, Biswal SB and Mohapatra S: Pattern of adverse drug reactions in a tertiary care hospital in Western Odisha. Int J Pharm Sci Res 2018; 9(6): 2471-77. doi: 10.13040/IJPSR.0975-8232.9(6).2471-77.
All © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
Article Information
40
2471-2477
379
1176
English
IJPSR
S. K. Behera, B. Rath *, S. B. Biswal and S. Mohapatra
Department of Pharmacology, VSS Institute of Medical Sciences and Research (VIMSAR), Burla, Sambalpur, Odisha, India.
rathbhabagrahi@gmail.com
22 August, 2017
03 November, 2017
12 November, 2017
10.13040/IJPSR.0975-8232.9(6).2471-77
01 June, 2018