PHARMACOKINETICS AND PHARMACODYNAMICS OF ELORES IN COMPLICATED URINARY TRACT INFECTIONS CAUSED BY EXTENDED SPECTRUM BETA-LACTAMASE STRAINS.
AbstractThe pharmacokinetic/pharmacodynamic indices generally predict the efficacy of antibiotics when used alone. The information related to these indices for the combination products and that too in cases of resistant bacterial infections is limited. The present study involved treatment of 12 subjects with severe complicated urinary tract infections caused by resistant extended spectrum beta lactamase bacterial strains with Elores; ceftriaxone and sulbactam combination with non-antibiotic adjuvant ethylenediamine tetracetate. In this study Elores 3g bd dose was administered and the pharmacokinetic/pharmacodynamic indices were evaluated. To see the impact of lower Elores dose on these indices, 3g od data was simulated using pharmacokinetic parameters from 3g bd dose. The pharmacokinetic/pharmacodynamic indices suggest that Elores 3g od can treat mild to moderate infection wherein minimum inhibitory concentration requirement is <16µg/mL; however for severe complicated urinary tract infections with resistant strains wherein the requirement is 16‑32µg/mL, Elores 3g bd should be the choice
Article Information
38
2569-78
621
2510
English
Ijpsr
V. S. Suresh Attili * and Manu Chaudhary
Bibi General Hospital and Cancer Centre , Malakpet, Hyderabad, Telangana, India
drsureshattili@gmail.com
28 October, 2014
28 December, 2014
14 February, 2015
10.13040/IJPSR.0975-8232.6(6).2569-78
01 June, 2015
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