PHYLOGENETIC ANALYSIS OF RAS SUBFAMILY PROTEINS
AbstractCancer is primarily an environmental disease with 90–95% of cases attributed to environmental conditions and 5–10% due to genetics.RAS proteins act as binary molecular switches and play an important role in intracellular signal transduction which regulates processes such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. The present bio-computational analysis was performed using web-based tools and servers. Multiple sequence alignment of selected human RAS subfamily proteins with other homologous sequences revealed highly conserved regions. The present work determined the physico-chemical properties of selected RAS proteins such as their hydrophilic nature; alpha–helical structure and close evolutionary relationship with higher vertebrates. Cancerous proteins (gi166706781, gi 4505451) from human having most of homology with the number of species. On the basis of this study we can suggest that these organisms can be taken for the further study and after the successful analysis, these can be implemented on humans
Article Information
22
1070-80
1346
1218
English
IJPSR
Diksha Jain, Ravita Rawat and Vinod Kumar Jatav *
Department of Biotechnology, MITS Gwalior, Madhya Pradesh, India
vinod.mits@gmail.com
04 September, 2015
06 November, 2015
12 December, 2015
10.13040/IJPSR.0975-8232.7(3).1070-80
01 March, 2016
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