PHYSICOCHEMICAL CHARACTERISATION AND DISSOLUTION PROPERTIES OF EFAVIRENZ- β CYCLODEXTRIN SOLID BINARY SYSTEMSAbstract
Efavirenz (EFA) solid binary systems were prepared with β-CD by co-grinding and microwave irradiation methods. Detection of inclusion complexation was done in solution state by means of phase solubility analysis and in solid state by FTIR, DSC and in-vitro Dissolution studies. Apparent stability constant revealed EFA with β-CD at 1:1 M produces stiochometric complex with AL type phase solubility profile. A true inclusion of EFA with β-CD at 1:2 M in solid state was confirmed by FTIR and DSC. Dissolution properties of EFA- β-CD binary systems were superior when compared to physical mixture and pure drug. Overall the rank order of improvement in dissolution properties of Efavirenz with ratios is 1:2M > 1:1M and methods MW > CG > PM > pure drug. One way ANOVA suggest the DP60 and DE60 values were significantly higher (P<0.01) in solid binary systems prepared by microwave irradiation method when compared to co-grinding and its corresponding physical mixtures and pure drug.
B. Arali *, A. Y. Kumar and M. C. Setty
Department of Pharmaceutics, East West College of Pharmacy, Vishwaneedam, Bengaluru, Karnataka, India.
17 April, 2018
05 July, 2018
13 July, 2018
01 December, 2018