PHYSICOTECHNICAL PROPERTIES OF PARACETAMOL TABLETS FORMULATED WITH THE GUM FROM THE FRESH LEAVES OF CORCHORUS OLITORIUS
AbstractCorchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% respectively. Its pharmaco-technical properties: friability, hardness, weight uniformity, disintegration time, percentage of fines, and angle of repose, were determined and compared with that of paracetamol produced from a commercial binder- Sodium carboxymethylcellulose (SCMC). The results obtained showed great promise and a comparative efficacy between the gum extract obtained from Corchorus olitorius L. and the SCMC.
Article Information
44
2676-2679
509KB
1299
English
IJPSR
U.E. Osonwa, E.M. Uronnachi*, C.E. Umeyor and C.C. Onwuzuligbo
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
emmauronnachi@gmail.com
16 April, 2012
15 May, 2012
29 July, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2676-79
01 August, 2012
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