POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’ TRIAL

Purpose: Several medications are currently available for trying smoking cessation, such as nicotine replacement therapy or antidepressants. This study investigates potential effect of Meclezine-B6 combination; and B6 tablets administrated orally for possibility of reducing number of cigarettes smoked per day during 10 days. Methods: Using placebo control study. In which adult smokers’ volunteers were assigned to one of study groups; control (N=20) or meclizine-B6 (N=50) and B6 group (N=50). All volunteers take their medications as single daily dose at night and the start to report number of cigarettes smoked daily from day 1 to day 10 with reporting the side effects appeared during the study. Results: The results showed there was significant declining in number of cigarettes daily smoked as compared with day 1 of study especially in B6 group. In This group, also higher percentage of volunteers showed significant smoking declining as compared to meclizine-b6 and control group. And most common side effects reported were drowsiness and headache especially in meclizine-B6 group. The potential role of B6 in smoking may require further evaluation using different doses. Conclusions: Oral administration of vitamin B6 as single daily dose of 50mg alone or in combination with Meclizine 25 mg may result in declining in number of daily cigarettes smoking; the effect will occur more when B6 was used alone rather than in combination of Meclizine.