PRECLINICAL SCREENING MODELS FOR ANTIHISTAMINIC ACTIVITY: AN OVERVIEW
AbstractAntihistamines appear to be the mainstay in allergic reaction treatment. Allergy is rooted in the primary rejection reaction of parasites in which histamine derived from mast cells generates an immediate aggressive environment, and eosinophils are recruited for killing. Antihistamines are medicinal products used to treat allergic rhinitis, conjunctivitis, urticaria, cold and flu, tachyphylaxis, motion sickness, and acute allergic reactions. A vast number of animals can be used for this activity, with rodents (inbred mice and rats) and guinea-pigs being the most common models, which are easy to maintain and relatively economical compared to other available models. Therefore, animal models used in asthma are greatly useful in antihistaminic studies because they promise new insights into human allergic symptoms. The available in-vivo and in-vitro models are used to investigate the mechanism of action of drugs with antihistaminic activity. This work aims to bring all the different in-vivo animal models and in-vitro techniques together for conducting antihistaminic activity research.
Article Information
7
1875-1881
527 KB
630
English
IJPSR
G. Vanita Kanase * and Makarand Dnyandev Samant
Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
makarand.4509@gmail.com
26 June 2021
06 November 2021
28 March 2022
10.13040/IJPSR.0975-8232.13(5).1875-81
01 May 2022
Download