PREDICTION OF LD50 OF SOME COMMON PESTICIDES THROUGH QSAR (AN ALTERNATIVE METHOD TO SAVE EXPERIMENTAL ANIMALS)Abstract
The most common test of acute toxicity is the LD50 test. LD50 means, the lethal dose of a substance that will kills 50% of animals. But this requires large number of animals. To reduce the sacrifice of animals. In present study we are using QSAR based software T.E.S.T. (toxicity estimation search tool 4.1 version) for predicting oral LD50. For prediction of oral LD50 we have taken 100 insecticides, 40 fungicides and 40 herbicides. During our analysis we find that for experimental oral LD 50, 27 insecticides are highly (value between 5-50) and 36 are moderate potent (value between 50-500). For predicted oral LD 50 value, 24 insecticides are highly and 34 are moderate potent. For fungicides 3 experimental and 3 predicted are moderate potent. For herbicides 6 experimental and 7 predicted herbicides are moderate LD 50 potent.
S.P. Agrawal * and V.L. Saxena
Lecturer Dept. of Zoology D-A.V. (PG) College Kanpur, UP 208001, India.
10 May, 2014
07 July, 2014
18 August, 2014
01 December 2014