PREPARATION AND CHARACTERIZATION OF CIPROFLOXACIN LOADED TRANSDERMAL PATCHESAbstract
The aim of this research was to formulate a matrix-type transdermal therapeutic system containing drug ciprofloxacin with different ratios of hydrophobic (ethyl cellulose) polymer by solvent evaporation technique, using 15% w/w of dibutyl phthalate to the polymer weight, incorporated as plasticizer. Different concentrations of isopropyl myristate were used to enhance the transdermal permeation of Ciprofloxacin. Formulated transdermal films were physically evaluated with regard to thickness, weight variation and drug content. All prepared formulations showed good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. Formulation T3 showed best in-vitro skin permeation through goat skin as compared to all other formulations. The release profile of the optimized formulation T3 indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation T3 showed highest flux among all other formulations. These results indicate that the formulation containing highest amount of isopropyl myristate gives better penetration of ciprofloxacin through goat skin.