PREPARATION AND EVALUATION OF FLOATING MICRO BEADS FOR GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF ANTIULCER DRUG
AbstractThe objective of the present investigation was to develop an alginate-HPMC K4M microbead-based gastro-retentive drug delivery system incorporating Famotidine for the treatment of gastrointestinal ulcers. The 32 full factorial designs were used for the optimization of famotidine-loaded floating microbeads. Two factors were evaluated, each at 3 levels; experimental trials were performed for all nine possible combinations. The amount of HPMC K4M (X1) and rotations of stirring speed (X2) were selected as independent variables. The % entrapment efficiency, % drug release at 12 hr, and % buoyancy were selected as dependent variables. The morphological properties, mean particle size, drug entrapment efficiency, drug loading, in-vitro buoyancy studies, in-vitro drug release, and in-vivo antiulcer activity of microbeads were all investigated. The effect of formulation variables on the response variables was statically evaluated by applying ANOVA at a 0.05 level using the software Design Expert® 13 (Stat-Ease, USA). The average size of optimized alginate-HPMC K4M microbeads was 0.86±0.35mm, with estimated entrapment effectiveness of 71.43± 0.21%, cumulative drug release of 98.75± 0.50% and percent buoyancy of 88.82±0.26%. Alginate – HPMCK4M microbeads containing Famotidine were successfully prepared using full 32 factorial designs and can be utilized to treat peptic ulcers efficiently. In-vivo, antiulcer activity indicated that the improved microbeads formulation might prevent ulcer formation in rats’ stomachs. The method presented appears to be promising for drug delivery to the stomach.
Article Information
46
3792-3806
2952 KB
393
English
IJPSR
Abhishek Kumar and Meenakshi Bharkatiya *
Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, India.
meenakshibharkatiya@gmail.com
01 July 2022
24 August 2022
25 August 2022
10.13040/IJPSR.0975-8232.13(9).3792-06
01 September 2022