PREPARATION AND EVALUATION OF MUCOADHESIVE GELLAN GUM IN-SITU GELS FOR THE OCULAR DELIVERY OF CARBONIC ANHYDRASE INHIBITOR NANOVESICLES
AbstractA novel approach was tested utilizing mucoadhesive in-situ gelling (ISG) Gellan Gum /HPMC solutions containing dispersions of methazolamide (MZA) loaded Spanlastic Vesicular systems (SVs). The tested systems were designed to combine high corneal permeability of SVs as well as ease of application and prolonged eye retention of ISGs. SVs consisted of Span 60 mixed with different ratios of edge activators (EA) (Tween 60, Tween 80, Brij 35 and Brij 58) were initially prepared and examined to select formulae that had small vesicle size and high drug entrapment. The evaluation of SVs systems included measurement of particle sizes, entrapment efficiencies (EE %) and relative deformability. SVs in ISG systems were characterized by in vitro release, viscosity, intraocular pressure (IOP) measurement after their administration to rabbit eyes and histopathological examination. It was found that SVs containing 10% Tween 60 (90:10) in ISG solutions (SG1) produced the highest reduction in IOP with the highest prolongation of MZA effect
Article Information
13
3761-74
669
1966
English
Ijpsr
Rania Elazreg, Mahmoud Soliman *, Samar Mansour and Abdelhameed El Shamy
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
mahmoud.e.soliman@pharma.asu.edu.eg
06 March, 2015
10 April, 2015
24 June, 2015
10.13040/IJPSR.0975-8232.6(9).3761-74
01 September, 2015
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