PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF FLUOXETINE HCl
AbstractThe aim of this research was to formulate and evaluate microspheres of Fluoxetine Hydrochloride. It is a selective inhibitor of serotonin reuptake type of drug used in the treatment of depression. It is practically soluble in water belongs to BCS class I with a bioavailability approximately 72%. Fluoxetine HCl mucoadhesive microspheres were prepared by using chitosan polymer and emulsion solvent evaporation method which enhance bioavailability of drug. Microsphere with particle size in the range 192.92µm to 251.18µm was prepared. Fluoxetine HCl microspheres were evaluated for mean particle size, the percentage yield, entrapment efficiencies, in-vitro release, in vitro mucoadhesive, FTIR, DSC, X-ray diffraction studies and stability study. Formulation F9 microspheres batch was found to be optimized and followed zero-order release kinetic. The optimized formulation was mucoadhesive in nature. Stability studies were carried out for F9 at a temperature of 40±2 °C/RH 75±5% formulation revealed that the drug behaviour was within permissible limits.
Article Information
17
3776-3785
613
1503
English
IJPSR
M.T. Deshmukh *and S. K. Mohite
Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India.
madhurideshmukh9@yahoo.com
25 February, 2017
06 April, 2017
15 April, 2017
10.13040/IJPSR.0975-8232.8(9).3776-85
01 September, 2017
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