PREPARATION, CHARACTERIZATION AND EVALUATION OF TABLET FOR COLONIC DELIVERYAbstract
The aim of the present work is to develop and evaluate colon targeted drug delivery of satranidazole for an effective and safe therapy of amoebiasis. Amoebiasis is a parasitic disease caused by E. histolytica and it causes about 34 – 50 million symptomatic infections each year. The treatment of amoebiasis is effective with satranidazole. Therefore it was planned to develop a suitable dosage form, which can deliver maximum amount of the drug in the colonic environment such that there would be effective action on amoebiasis. This investigation was planned to characterize the satranidazole for their physico-chemical properties and to evaluate rheological and compressional characteristics of the tablets. It was planned to optimize the amount of PH dependent polymer eudragit L100 and eudragit S100 carriers for colonic delivery. The coating formulation consisted of Eudragit L100: Eudragit S100 in ratio of 6:4 at 10% coating level has potential for the required lag time of 5 hours. In-vitro release study was shown after effective lag time.
P. M. Chavan * and S. Ughade
Department of Pharmaceutics, Shree Sainath College of Pharmacy, Dawalamethi, Nagpur, Maharashtra, India.
28 July, 2017
12 October, 2017
20 October, 2017
01 May, 2018