PREPARATION, OPTIMIZATION AND CHARACTERIZATION OF LETROZOLE NANOLIPOSOMES

Objective: Nanoliposomes of letrozole a drug used for breast cancer treatment were formulated. The present investigation was aimed to optimize the phospholipids concentration by formulating a series of nanoliposomes formulation and their characterization. Methods: Nanoliposomes were prepared using reverse-phase evaporation technique employing diverse ratios of soya lecithin and cholesterol concentration. The effect of various factors was studied on size, polydispersity index, loading capacity and entrapment efficiency of nanoliposomes. The prepared nanoliposomes were analyzed using DSC and ATR spectroscopy for drug-excipients compatibility. Results: The smallest particle size and polydispersity index (99.45, 0.262) highest entrapment (87.24 ± 0.59) and loading capacity (56.89 ± 0.39) was observed in batch NL8. The disappearance of drug peak in DSC indicates the dissolution of the drug in a polymer matrix. The ATR spectroscopy results show there was no interaction between components and drug is stable in the formulated nanoliposomes. Conclusion: It is concluded that the concentration of soya lecithin and cholesterol were critical parameters that affect the encapsulation of letrozole in the formulation and optimization of nanoliposomes.