PROTECTIVE EFFECTS OF ALOE VERA AGAINST RADIATION INDUCED BIOCHEMICAL DISORDERS IN LIVER OF SWISS ALBINO MICE
AbstractIn this study, radioprotection against radiation-induced hepatic damage in Swiss albino mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure 0.5, 3 and 5.5 Gy gamma radiation. Mice were autopsied at day ¼, 1, 3, 5, 10 and 20 after irradiation to evaluate the radio modulator effect in terms of protein, cholesterol, and glycogen. In control set animals radiation treatment showed an increase of protein, glycogen, and cholesterol, however, the animals of experimental group, i.e., Aloe vera and radiation combined group showed a significant decrease in protein, glycogen and cholesterol but values remained below normal. It can be concluded that Aloe vera modulate the radiation-induced biochemical alterations in Swiss albino mice.
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