PTEN-A REVIEW
AbstractPTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general physiological activity. Various cellular proteins are initiated by phosphorylation; in contrast, PTEN is deactivated based on phosphorylation by specific kinases. Therefore, the development of therapeutic agents includes selectively targeting quickness and kinase-domain containing proteins affecting PTEN associated diseases. The present review focuses on the role of PTEN in pathological conditions and a comprehensive list of currently identified modulators of PTEN and explains potential new molecular targets which could be help in the development of drugs for the management of PTEN associated diseases like cardiovascular diseases, diabetes, obesity, cancer, autism, and Alzheimer’s diseases.
Article Information
4
35-40
607
902
English
IJPSR
M. Mayuri and G. V. N. Kumar *
Department of Pharmacology, Drug Standardization Unit, Dr. D. P. Rastogi Central Research Institute for Homeopathy, Noida, Uttar Pradesh, India.
mayuri.jayanag@gmail.com
16 April 2019
03 August 2019
13 August 2019
10.13040/IJPSR.0975-8232.11(1).35-40
01 January 2020
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