QUANTITATIVE DETERMINATION OF PIPERACILLIN BY IODOMETRIC METHOD USING POTASSIUM PEROXOMONOSULFATE
AbstractKinetics and stoichiometry S-oxidation reaction of sodium piperacillin by means of potassium hydrogen peroxomonosulfate in aqueous solutions using iodometric titration were studied. Zopercin® – powder in vials for piperacillin injection solution in the combined form with tazobactam (piperacillin 4.0 g and tazobactam 0.5 g) was used for analysis. A new iodometric method for quantitative determination of sodium piperacillin in Zopercin® preparation using potassium hydrogen peroxomonosulfate (KHSO5) as analytical reagent was proposed. Peroxomonosulfate acid as triple potassium salt 2KНSO5∙KНSO4∙K2SO4 (Oxone®) of “extra pure” qualification was used as oxidant. At pH 2-4 for 1 mole of penicillin, 1 mole of KHSO5 is consumed; the quantitative interaction is achieved within a time of more than 1 minute (observation time). The results were obtained by the recommended procedure for seven replicate titrations of mixtures containing the three species at various concentrations. RSD = 1.15 %, δ = (+0.2) %. It can be seen that piperacillin can be determined successively with good accuracy and reproducibility. The new procedure was developed and ability of quantitative determination of penicillin in pharmaceutical preparation Zopercin® by iodometric method using potassium hydrogen peroxomonosulfate (KHSO5) as analytical reagent was shown.
Article Information
51
3015-3019
488
1050
English
IJPSR
S. P. Karpova *, M. Y. Blazheyevskiy, O. O. Mozgova, Y. Y. Serdiukova, M. M. Ivashura and I. Y. Petukhova
Department of Physical and Colloid Chemistry, National University of Pharmacy, Pushkinska Street, Kharkiv, Ukraine.
za9594506@gmail.com
23 October, 2017
20 December, 2017
25 December, 2017
10.13040/IJPSR.0975-8232.9(7).3015-19
01 July, 2018