QUERCETIN LOADED POLY VINYL ALCOHOL- ALGINATE HYDROGEL ATTENUVATES INFLAMMATION
AbstractThe flavonoid compound quercetin is widely acknowledged for its diverse biological properties including anti-inflammatory, antioxidant, anti-bacterial, anti-ageing, anticancer however the constraints like poor solubility, low bioavailability, lack of stability and decreased permeability limits its pharmacological applications. Hydrogel assisted delivery systems especially for transdermal delivery of phytochemicals like quercetin is being suggested but least explored for its efficacy as an anti-inflammatory system. A PVA – alginate system was synthesized with quercetin and was explored for its effect as a potent anti-inflammatory system. The synthesized hydrogel was found to exhibit 56% loading efficiency and shown a sustained release over time as determined using HPLC analysis. The hydrogel system exhibited appreciable inhibition of total COX, 5 LOX, iNOS activity, Nitrate levels and MPO activity in RAW macrophage cells when compared with LPS alone treated groups affirming anti-inflammatory potential which can find applications in development of therapeutic regimens which will emphasize an economical, highly effective and risk-free plant drug with minimum side effects.
Article Information
12
112-119
1005 KB
816
English
IJPSR
Gouri Parvathy, Nithin Vijayakumar and Rajesh Ramachandran *
Department of Molecular Biology, Center for Research on Molecular and Applied Sciences (P) Ltd., Thiruvananthapuram, Kerala, India.
info@crmas.in
22 May 2023
19 September 2023
20 September 2023
10.13040/IJPSR.0975-8232.15(1).112-19
01 January 2024
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