RECENT ADVANCEMENT IN THE DEVELOPMENT OF THERAPEUTIC PEPTIDES
AbstractPeptides are naturally occurring biologics, which provide essential functions as hormones, growth factors, biological messengers, anti-infective, neurotransmitters, and antimicrobials. Peptide hormones such as insulin, vasopressin, oxytocin, and gonadotropin-releasing hormone have significantly accelerated advances in modern drug development fields, including biology, chemistry, pharmacology, and other cutting-edge technologies. This review article described the peptides, their different sources and production processes, and how they are synthesized. Peptides are highly desirable as therapeutic agents due to their unique properties, which are determined by their physicochemical and proteolytic stability profiles. Numerous techniques are being developed to enhance the therapeutic profile of peptides, such as side chain modification, cyclization, N-methylation, peptoids, and substitution with D-amino acids inclusion in delivery systems and halogenation. Peptides are therapeutically used in the management of several diseases; the potential range of peptide-based medications is being extended to new targets by ongoing research.
Article Information
3
2454-2467
682 KB
562
English
IJPSR
Shivam Kumar and Vivek Srivastava *
Amity Institute of Pharmacy, Amity University, Lucknow Campus, Uttar Pradesh, India.
srivastavav696@gmail.com
01 March 2025
28 April 2025
30 June 2025
10.13040/IJPSR.0975-8232.16(9).2454-67
01 September 2025
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