ROLE OF ACUTE PHASE PROTEINS STATUS IN CHRONIC ALCOHOLIC LIVER DISEASES

Back ground: Alcoholic cirrhosis is a condition of irreversible liver disease due to the chronic inflammatory and toxic effects of ethanol on the liver. Acute alcoholic hepatitis occurs in habitual drinkers, often a period of increased alcohol intake. Although, the clinical features may mimic acute viral hepatitis. Progression of liver fibrosis to cirrhosis is dangerous as well as potentially life-threatening condition that occurs when inflammation and scarring damage. Several biochemical parameters are altered in this condition .A combination of tests are useful for diagnosis of cirrhosis.

Aim & objective: The aim of the study evaluates the possible association between the acute phase proteins along with other biochemical parameters in alcoholic liver disease.

Materials and methods: A total 30 chronic alcoholic liver disease patients between the ages of 32 and 60 years are selected for the study group, 30 healthy age matched healthy individuals are selected as a control group. All the parameters are analyzed by conventional standardized methods and compared between the two groups.

Results: The mean levels of acute phase proteins Transferrin, alpha 1 antitrypsin are significantly decreased. CRP and sialic acid levels are significantly increased chronic alcoholic liver disease patients.

Conclusion: Evaluation of plasma acute phase proteins (transferrin, alpha 1 antitrypsin, CRP) & sialic acid   are potentially useful diagnostic markers for the assessment of chronic alcoholic liver disease along with other biochemical parameters.