ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
AbstractAn experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perfusion apparatus (Langendorff apparatus). The experiment was divided into three phases, perfusion (15 min) followed by ischemia (10 min) followed by reperfusion (15 min). LDH level of perfusate and coronary flow were taken as biochemical and physiological marker of myocardial reperfusion injury respectively and were measured at 5, 10 and 15 min of post ischemic period. Control and test groups were compared. The result shows that in the group receiving oral iron chelator, deferasirox, the decrease in post ischemic LDH level was significant (p< 0.01) at 5, 10 and 15 min while there was significant increase in post ischemic coronary flow at 5 min (p< 0.01) as compared with control. Thus oral iron chelator, deferasirox has protective role in prevention of myocardial ischemic reperfusion injury in albino rabbits
Article Information
34
2558-62
316
1021
English
IJPSR
G. Gambhir *, A. K. Gupta , P. Agrawal, V. Kushwaha, A. Singh, IP Jain, A. N. Singh and P. Tripathi
Department of Pharmacology, Ganesh Shankar Vidyarthi Memorial (GSVM) Medical College, Kanpur, Uttar Pradesh, India
arbitnumb@hotmail.com
19 January, 2016
01 March, 2016
08 May, 2016
10.13040/IJPSR.0975-8232.7(6).2558-62
01 June 2016
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