ROLE OF LOCUST OLFACTORY TO DETECT CANCER
AbstractLocusts are well-known for their exceptional sense of smell, are emerging as potential bio-hybrid sensors that could be used in cancer detection. This review analyses the possible ways to develop their sensitive olfactory systems to detect volatile organic compounds (VOCs) released by cancer cells. Around 50,000 receptors remain present on the antennae of locusts, are capable to specify cancerous samples from non-cancerous matters. Recent review discussed about the possibility of coupling locust olfactory with bioelectronic devices or biosensingrobotic systems for cancer diagnosis. Locust olfactory receptor neurons (ORNs) are capable to detect fumes of VOCs and send signals through antennal lobes to projection neurons (PNs) where the signals are transformed to identifiable neural patterns. Again olfactory lobes are easy to modify by tissue culture. While the biohybrid concept is still incomplete and faced with issues of scalability and specificity, it has the potential to detect early-stage cancer.
Article Information
7
3233-3247
1225 KB
3
English
IJPSR
S. Saha, B. Bhattacharyakundu *, B. K. Chakra and Nadhikari
PG Institute of Medical Sciences, Chandrakona Town, Paschim Medinipur, West Bengal, India.
bidyutparna88@gmail.com
19 May 2025
18 June 2025
21 June 2025
10.13040/IJPSR.0975-8232.16(12).3233-47
01 December 2025
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