SELENIUM AND CHROMIUM AS ANTIDIABETIC TRACE ELEMENTS: AN OVERVIEW
AbstractTrace elements are the dietary factors required by the body in small quantities for normal functioning of the body. The body’s functional skill is negatively impacted by a diet with insufficient trace elements, which lowers the body’s immune function. They are involved in catalyzing different enzymatic reactions. The permissible range of selenium is very narrow. Low levels of selenium have been reported in patients suffering from both acute and chronic kidney diseases. Reduced levels of selenium have also been reported in diabetic patients, while excess levels of selenium have been linked with inflammation and increased oxidative stress. Selenium at optimum amounts decreases oxidative stress by functioning as a cofactor of glutathione peroxidases and thioredoxin reductases. Insufficient intake of chromium leads to reduced insulin activity, hinder protein synthesis thereby leading to Type 2 diabetes mellitus. Chromium have been reported to boost enzyme activity and play crucial role in carbohydrate metabolism, increase sugar metabolism by initiation of insulin. This review aims to encompass the mechanism of action in prevention of diabetes mellitus of selenium and chromium.
Article Information
7
681-689
960 KB
245
English
IJPSR
B. Sarma and P. Saha *
Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Rd, Sahid Colony, Panihati, Kolkata, West Bengal, India.
prerona.saha@gnipst.ac.in
03 July 2023
12 October 2023
23 November 2023
10.13040/IJPSR.0975-8232.15(3).681-89
01 March 2024
Download