SIMULTANEOUS ESTIMATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE BY SPECTROSCOPIC METHODS
AbstractA novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Mefenamic acid and Dicyclomine hydrochloride in combined dosage form. Three different analytical methods, Absorption correction method, Differential derivative method, Simultaneous equation method were developed for estimation of Dicyclomine hydrochloride(10mg) and Mefenamic acid (250mg) in tablet dosage form. wavelength for estimation was 223nm for Dicyclomine hydrochloride and 308.60nm for Mefenamic acid in absorption correction method. 211.60nm was Zero crossing point of Mefenamic acid and 308.80nm was Zero crossing point of Dicyclomine hydrochloride which can estimate in differential derivative method. Simultaneous equation method was developed in NaOH which was linear in the range of 1-6µg/ml for Dicyclomine hydrochloride and 25-150µg/ml for Mefenamic acid, the correlation coefficient obtained was nearer to one. The method was validated for linearity, accuracy and precision as per ICH guidelines. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form
Article Information
31
3766-3776
925KB
2726
English
Ijpsr
Dipal Prajapati* and Hasumati Raj
Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim-Kudsad Road, Kim, Surat-394110, Gujarat, India
dipalprajapati13@yahoo.com
02 June, 2012
19 June, 2012
28 June, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3766-76
01 October, 2012
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