SLEEP-INDUCING EFFECTS OF MULBERRY LEAVES TO TREAT INSOMNIA NATURALLY

Sleep disorders are a prevalent health concern, impacting overall well-being and cognitive function. Natural compounds like flavonoids have garnered attention for their potential therapeutic effects on sleep regulation. Mulberry leaves (Morus spp.) are rich in bioactive flavonoids that exhibit sleep-improving properties by modulating key neurotransmitter systems. This study explores the effects of mulberry leaves on sleep regulation through their interaction with gamma-aminobutyric acid (GABA) and serotonin (5-hydroxytryptamine, 5-HT) receptors. Evidence suggests that these flavonoids enhance GABAergic transmission, promoting relaxation and sedation, while also modulating 5-HT receptors, that contribute notably to the regulation of sleep-wake cycles. Many flavonoids, including quercetin, rutin, and kaempferol, are able to interact with GABAA receptors and serotonin receptors, promoting relaxation and reducing sleep latency. By influencing these neurotransmitter pathways, mulberry leaf flavonoids may serve as a natural and effective alternative for managing sleep disturbances or insomnia. Additional studies are required to better understand the exact mechanisms as well as potential clinical uses of these bioactive compounds in sleep therapy.