SOLID LIPID NANOPARTICLES: AN ADVANCED DRUG DELIVERY SYSTEM
AbstractSolid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. Solid lipid nanoparticles (SLNs) technology represents a promising new approach to lipophilic drug delivery. Solid lipid nanoparticles are spherical lipid particles ranging in size from 1 to 1000 nm and are dispersed in water or in aqueous surfactant solution. It is identical to an oil-in-water emulsion, but the liquid lipid (oil) of the emulsion has been replaced by a solid lipid, i.e., yielding Solid Lipid Nanoparticles. SLN are particles made from solid lipid or lipid blends produced by high pressure homogenization. The biodegradable and bioacceptable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. SLNs can also be used to improve the bioavailability of drugs. In this present review this new approach is discussed in terms of their advantages, disadvantages, methods, characterization, pharmacokinetic studies, in-vivo studies, in-vitro studies, and special features
Article Information
17
161-171
596KB
1625
English
IJPSR
Raghu Nandan Reddy* and Arshia Shariff
Department of pharmaceutics, Krupanidhi College of pharmacy, Sarjapura main road, Carmelaram post, Bangalore-560035, Karnataka, India
crraghunandanreddy@gmail.com
26 September, 2012
30 October, 2012
15 December, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).161-71
01 January, 2013
Download