SOLID LIPID NANOPARTICLES FOR ENHANCEMENT OF ORAL BIOAVILABILITY OF CEFPODOXIME PROXETIL

Solid lipid nanoparticles (SLNs) have been proposed as suitable colloidal carriers for delivery of drugs with poor bioavailability. The objective of this study was to develop and evaluate solid lipid nanoparticles of Cefpodoxime Proxetil (CP) for enhancement of bioavailability via its lymphatic absorption. Solvent evaporation technique was adopted to prepare Cefpodoxime Proxetil loaded SLN with Precirol ATO 5 as a carrier with narrow size distribution. The mean particle size, drug entrapment efficiency (%), zeta potential and long term physical stability were investigated in detail. Drug release from Cefpodoxime Proxetil- Solid lipid nanoparticles (CP-SLN) was studied using a Franz diffusion cell. A pharmacokinetic study was conducted on male rats after oral administration of CP and CP-SLN. It was found that the relative bioavailability of CP with SLNs was significantly increased as compared with oral CP suspension. FTIR and DSC study revealed that drug is completely encapsulated in lipid matrix. Dry powder for reconstitution was selected as dosage form for the oral administration of CP-SLNs. These results indicated that bioavailability of CP was improved when formulated as SLNs due to its lymphatic absorption.